olid lipid nanoparticles loaded with curcumin: development and in vitro toxicity against CT26 cell

Author(s):Show less -

Ganassin, Rayane ^{[1, 2]} ; da Silva, Victor Carlos Mello ^{[1, 2]} ; Araujo, Victor Hugo Sousa ^{[1, 2]} ; Tavares, Giulia Rosa ^{[1, 2]} ; da Silva, Patricia Bento ^[1] ; Caceres-Velez, Paolin Rocio ^{[1, 3, 2, 4]} ; Porcel, Joaquin E. Martinez ^[4] ; Rodrigues, Mosar Correa ^[1] ; Andreozzi, Patrizia ^[4] ; Fernandes, Richard Perosa ^[5] ; Fonseca-Santos, Bruno ^[6] ; Moya, Sergio ^[4] ; Azevedo, Ricardo Bentes ^[1] ; Chorilli, Marlus ^[7] ; Muehlmann, Luis Alexandre ^{[1, 2]}

Affiliation

^[1] Univ Brasilia, Inst Biol Sci, Dept Genet & Morphol, BR-70910900 Brasilia, DF - Brazil

^[2] Univ Brasilia, Fac Ceilandia, Lab Nanosci & Immunol, BR-72220900 Brasilia, DF - Brazil

^[3] Univ Melbourne, Sch BioSci, Parkville, Vic 3010 - Australia

^[4] Ctr Cooperat Res Biomat CIC BiomaGUNE, Soft Matter Lab, San Sebastian - Spain

^[5] Sa Paulo State Univ, Chem Inst, Lab Thermal Anal Ivo Giolitto, Araraquara, SP - Brazil

^[6] Univ Campinas UNICAMP, BR-13083871 Campinas, SP - Brazil

^[7] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil

• Document type: Journal article
• Source: Nanomedicine; v. 17, n. 3, p. 167-179, FEB 2022.
• Web of Science Citations: 0

Abstract

Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media. (AU)

• FAPESP's process: 19/10261-2 - Evaluation of the potential of nanostructured lipid carriers for co-encapsulation of curcumin and fluconazole dispersed in thermally-responsive hydrogels in the treatment of vulvovaginal candidiasis
• Grantee: Victor Hugo Sousa Araujo
• Support Opportunities: Scholarships in Brazil - Doctorate