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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ssessment of laboratory tests and intraoperative bleeding in patients with liver cirrhosis undergoing tooth extraction

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Author(s):
Franco, Juliana Bertoldi [1] ; Andrade, Natalia Silva [2] ; Rodrigues da Silva Bueno, Marcus Vinicius [3] ; Siqueira de Melo Peres, Maria Paula [1] ; Medina, Janaina B. [4] ; Tenorio, Jefferson da Rocha [3] ; Rech, Bruna de Oliveira [3] ; Ortega, Karem L. [3]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Clin Hosp, Sch Med, Div Dent, Sao Paulo - Brazil
[2] Univ Fed Sergipe, Dept Dent, Lagarto, Sergipe - Brazil
[3] Univ Sao Paulo, Sch Dent, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508000 Sao Paulo, SP - Brazil
[4] Mario Covas State Hosp Santo Andre, Div Dent, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 133, n. 2, p. 148-155, FEB 2022.
Web of Science Citations: 0
Abstract

Objectives. The objective of this study was to quantify intraoperative bleeding in patients with cirrhosis and correlate it with clinical characteristics and laboratory coagulation tests. Study Design. A case-control study was carried out with 74 patients with cirrhosis who were submitted to preoperative coagulation tests (complete blood count, platelet count, prothrombin time/international normalized ratio, thrombin time, activated partial thrombin time, platelet aggregation, fibrinogen, protein C, protein S, antithrombin, and von Willebrand factor level and activity). The levels of nitrogen compounds that can affect the platelet function were determined in saliva and blood by using automated enzymatic-colorimetric assays. Results. Patients with cirrhosis had changes in almost all coagulation tests. The average volumes of intraoperative bleeding and blood lost per minute in the study group (5.36 mL/min and 0.19 mL/min, respectively) were greater than those in the control group (3.05 mL/min and 0.11 mL/min, respectively; P < .05). In the control group, ascites (P = .012) and presence of periapical lesion (0.034) were positively correlated with bleeding (mL/min). With regard to coagulation tests and nitrogen compounds, only a positively moderate correlation with the platelet aggregation test was observed. Conclusions. No patients had hemorrhagic events and it was not possible to correlate a greater amount of bleeding with coagulation tests or nitrogen compounds in the study group. (AU)

FAPESP's process: 17/18938-6 - Evaluation of oral health and post-exodontic bleeding in pre-transplant patients.
Grantee:Karem López Ortega
Support Opportunities: Regular Research Grants