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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

hat can we learn from commercial insecticides? Efficacy, toxicity, environmental impacts, and future development

Full text
Author(s):
Rezende-Teixeira, Paula [1] ; Dusi, Renata G. [2] ; Jimenez, Paula C. [3] ; Espindola, Laila S. [2] ; Costa-Lotufo, V, Leticia
Total Authors: 5
Affiliation:
[1] V, Univ Sao Paulo, Inst Ciencias Biomed, Dept Farmacol, Lab Farmacol Marinha, BR-05508900 Sao Paulo, SP - Brazil
[2] Univ Brasilia, Lab Farmacognosia, Campus Univ Darcy Ribeiro, BR-70910900 Brasilia, DF - Brazil
[3] Univ Fed Sao Paulo, Inst Mar, Lab Bioprospeccao Organismos Marinhos, Santos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Environmental Pollution; v. 300, MAY 1 2022.
Web of Science Citations: 0
Abstract

Worldwide pesticide usage was estimated in up to 3.5 million tons in 2020. The number of approved products varies among different countries, however, in Brazil, there are nearly 5000 of such products available. Among them, insecticides correspond to a group of mounting importance for controlling crop pests and diseaseassociated vectors in public health. Unfortunately, resistance to commercially approved insecticides is commonly observed, limiting the use of these products. Thus, the search for more effective and environmentally friendly products is both a challenge and a necessity since several insecticides are no longer allowed in many countries. In this review, we discuss the historical strategies used in the development of modern insecticides, including chemical structure alterations, mechanism of action and their impact on insecticidal activity. The environmental impact of each pesticide class is also discussed, with persistence data and activity on non-target organisms, along with the human toxicological effect. By tracing the historical route of discovery and development of blockbuster pesticides like DDT, pyrethroids and organophosphates, we also aim to categorize and relate the successful chemical alterations and novel pesticide development strategies that resulted in safer alternatives. A brief discussion on the Brazilian registration procedure and a perspective of insecticides currently approved in the country was also included. (AU)

FAPESP's process: 17/09022-8 - Inhibitory Apoptosis Proteins (IAPs) as therapeutic targets in melanoma: studies with prodiginines in vemurafenibe-resistant cells
Grantee:Paola Cristina Branco
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/50926-0 - INCT 2014: biodiversity and natural products
Grantee:Vanderlan da Silva Bolzani
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 15/17177-6 - Integrative approach on the sustainable prospection of marine natural products: from diversity to anticancer compounds
Grantee:Leticia Veras Costa Lotufo
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 17/17648-4 - Integrative approach on the sustainable prospection of marine natural products: from diversity to anticancer compounds
Grantee:Anelize Bauermeister
Support Opportunities: Scholarships in Brazil - Post-Doctoral