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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

he Role of ANP Level Response in Interdisciplinary Weight Loss Therapy on Cardiometabolic Risk and Body Composition in Adolescents with Obesit

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Author(s):
Pelissari Kravchychyn, Ana Claudia [1] ; da Silveira Campos, Raquel Munhoz [2] ; Martins Ferreira, Yasmin Alaby [1] ; de Castro Ferreira Vicente, Sofia Emanuelle [1, 3] ; Corgosinho, Flavia Campos [4] ; Oyama, Lila Missae [1] ; Boldarine, Valter Tadeu [1] ; Tock, Lian [1] ; Thivel, David [5] ; Damaso, Ana Raimunda [1]
Total Authors: 10
Affiliation:
[1] Univ Fed Sao Paulo, Programa Posgrad Nutr, Rua Botuvatu 862, BR-04024002 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Biociencias, Programa Posgrad Interdisciplinar Ciencias Saude, Campus Baixada Santista, Santos, SP - Brazil
[3] Anhanguera Educ Lida, Guarulhos, SP - Brazil
[4] Univ Fed Goias, Nutr, Goiania, Go - Brazil
[5] Univ Clermont Auvergne, Clermont Ferrand, Auvergne Rhone - France
Total Affiliations: 5
Document type: Journal article
Source: Arquivos Brasileiros de Cardiologia; v. 118, n. 1, p. 33-39, 2022.
Web of Science Citations: 0
Abstract

Background: The action of atrial natriuretic peptide (ANP) on natriuresis, diuresis and vasodilatation, insulin resistance, liver, kidney, and adipose tissue may contribute to the healthy metabolic and cardiovascular development. Even though the circulating level of ANP is reduced in patients with obesity, its response to weight loss remains poorly explored in pediatric populations. Objective: To evaluate the effects of ANP variations in response to interdisciplinary weight loss intervention on metabolic syndrome (MetS) and cardiometabolic risks in adolescents with obesity. Methods: 73 adolescents with obesity attended a 20-week clinical interdisciplinary weight loss therapy including clinical, nutritional, psychological and exercise training approach. Body composition, biochemical analyses and blood pressure were evaluated. MetS was classified according to the International Diabetes Federation (IDF) (2007). After the treatment, volunteers were divided according to Increasing (n=31) or Decreasing (n=19) ANP plasma levels. Results: Both groups present significant reduction of body weight, Body Mass Index (BMI), waist, neck and hip circumferences (WC, NC and HC, respectively) and increasing fat-free mass (FFM). Interestingly, a significant reduction in body fat, TG/HDL-c ratio and MetS prevalence (from 23% to 6%) was observed in the Increased ANP group only. Conclusion: This study suggests that an increase in ANP serum levels after weight loss therapy could be associated with improvements in cardiometabolic risks and the reduced prevalence of MetS in adolescents with obesity. (AU)

FAPESP's process: 17/07372-1 - New frontiers in the fight against obesity: digital health education as supporting in the interdisciplinary clinical process
Grantee:Ana Raimunda Dâmaso
Support Opportunities: Regular Research Grants
FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support Opportunities: Regular Research Grants
FAPESP's process: 15/14309-9 - Effects of Physical Exercise associate with Phototherapy on Adipogenesis Biomarkers and Transdifferentiation of Adipose Tissue in Adult Obese Women
Grantee:Raquel Munhoz da Silveira Campos
Support Opportunities: Scholarships in Brazil - Post-Doctoral