Association between beta-2 adrenergic receptor variants and clinical outcomes in children and adolescents with acute asthma

Author(s)

Fábio Pereira Muchão ^[1] ; Andréa Vieira de Souza ^[2] ; Juliana Miguita e Souza ^[3] ; Luiz Vicente Ribeiro Ferreira da Silva Filho ^[4]

Affiliation

^[1] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil

^[2] Hospital Israelita Albert Einstein. Instituto Israelita de Ensino e Pesquisa Albert Einstein - Brasil

^[3] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil

^[4] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil

• Document type: Journal article
• Source: Einstein (São Paulo); v. 20, 2022-03-25.

Abstract

ABSTRACT Objective To investigate whether different genotypes of p.Arg16Gly, p.Gln27Glu, p.Arg19Cys and p.Thr164Ile variants interfere in response to treatment in children and adolescents with moderate to severe acute asthma. Methods This sample comprised patients aged 2 to 17 years with a history of at least two wheezing episodes and current moderate to severe asthma exacerbation. All patients received multiple doses of albuterol and ipratropium bromide delivered via pressurized metered-dose inhaler with holding chamber and systemic corticosteroids. Hospital admission was defined as the primary outcome. Secondary outcomes were changes in forced expiratory volume in the first second after 1 hour of treatment, and for outpatients, length of stay in the emergency room. Variants were genotyped by sequencing. Results A total of 60 patients were evaluated. Hospital admission rates were significantly higher in carriers of the genotype AA relative to those with genotype AG or GG, within the p.Arg16Gly variant (p=0.03, test χ2, alpha=0.05). Secondary outcomes did not differ between genotypes. Conclusion Hospital admission rates were significantly higher among carriers of the genotype AA within the p.Arg16Gly variant. Trial registration: ClinicalTrials.gov: NCT01323010 (AU)

• FAPESP's process: 10/14848-3 - Efficacy and safety of increasing doses of inhaled albuterol administered by metered dose inhalers in children with acute wheezing episodes
• Grantee: Luiz Vicente Ribeiro Ferreira da Silva Filho
• Support Opportunities: Regular Research Grants