| Full text | |
| Author(s): |
Priscila Rezeck Nunes
[1]
;
Mariana Romao-Veiga
[2]
;
Vera Therezinha Medeiros Borges
[3]
;
Mariana Leticia Matias
[4]
;
Vanessa Rocha Ribeiro
[5]
;
Roberto Antonio Araujo Costa
[6]
;
Maria Terezinha Serrao Peracoli
[7]
;
Jose Carlos Peracoli
[8]
Total Authors: 8
|
| Affiliation: | [1] Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Medicina - Brasil
[2] Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Medicina - Brasil
[3] Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Medicina - Brasil
[4] Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Medicina - Brasil
[5] Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Medicina - Brasil
[6] Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Medicina - Brasil
[7] Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Medicina - Brasil
[8] Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Medicina - Brasil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | Revista Brasileira de Ginecologia e Obstetrícia; v. 43, n. 9, p. 669-675, 2021-11-29. |
| Abstract | |
Abstract Objective Preeclampsia (PE) is a pregnancy-specific syndrome characterized by abnormal levels of cytokines and angiogenic factors, playing a role in the disease development. The present study evaluated whether immunological markers are associated with the gestational age and with the disease severity in preeclamptic women. Methods Ninety-five women who developed PE were stratified for gestational age as preterm PE (< 37 weeks) and term PE (≥ 37 weeks of gestation) and compared for disease severity as well as plasma concentration of angiogenic factors and cytokines. The concentrations of placental growth factor (PlGF), vascular endothelial growth factor (VEGF), Fms-like soluble tyrosine kinase (sFlt-1) and soluble endoglin (sEng), as well as the cytokines, tumor necrosis factor-α (TNF-α) and interleukin 10 (IL-10), were determined by enzyme-linked immunosorbent assay (ELISA). Results The comparison between preeclamptic groups showed a higher percentage of severe cases in preterm PE (82.1%) than in term PE (35.9%). Similarly, the concentrations of TNF-α, sFlt-1, and sEng, as well as TNF-α/IL-10 and sFlt-1/PlGF ratios were significantly higher in the preterm PE group. In contrast, concentrations of PlGF, VEGF, and IL-10 were significantly lower in women with preterm PE. Negative correlations between TNF-α and IL-10 (r = 0.5232) and between PlGF and sFlt1 (r = 0.4158) were detected in the preterm PE. Conclusion In pregnant women with preterm PE, there is an imbalance between immunological markers, with the predominance of anti-angiogenic factors and TNF-α, associated with adverse maternal clinical outcomes. (AU) | |
| FAPESP's process: | 10/20207-0 - Involvement of innate immunity and placental factors in the pathophysiology of preeclampsia |
| Grantee: | Maria Terezinha Serrão Peraçoli |
| Support Opportunities: | Regular Research Grants |