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Gestational and lactational xenoestrogen exposure disrupts morphology and inflammatory aspects in mammary gland of gerbil mothers during involution

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Author(s):
Rocha Ruiz, Thalles Fernando ; Rivas Leonel, Ellen Cristina ; Colleta, Simone Jacovaci ; Bedolo, Carolina Marques ; Pegorin de Campos, Silvana Gisele ; Taboga, Sebastiao Roberto
Total Authors: 6
Document type: Journal article
Source: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY; v. 89, p. 13-pg., 2022-01-01.
Abstract

In the mammary gland (MG), the developmental window for gestational/lactational differentiation and growth is highly vulnerable to hormonal disruption. Here we describe that the MG involution process in female gerbil mothers is delayed by bisphenol A (BPA) exposure during gestation and lactation. The process is directly influenced by changes in expression of extracellular matrix proteases MMP-2, MMP-9, and FAP, and the incidence of collagen and elastin is reduced after 7 and 14 days of weaning. A pro-inflammatory environment in the late involution process was confirmed by higher expression of TNF-alpha, COX-2 and phospho-STAT3 n the MG stroma, allied to increases in the incidence of macrophages and mast cells. These aspects impacted the proliferative pattern of epithelial cells, which decreased on the 14th post-weaning day. These data confirm that the milk production window of susceptibility is vulnerable to the impact of BPA, which promotes a suggestive pro tumoral microenvironment during mammary involution. (AU)

FAPESP's process: 20/01240-9 - Late effects of bisphenol A exposure in the mammary gland of female gerbils during pregnancy and lactation
Grantee:Thalles Fernando Rocha Ruiz
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 18/23383-6 - Histopathological repercussions of the endocrine disrupters bisfienol-A and 17-beta-oestradiol on mammary glands and female prostate of the Mongolian Gerbil and their relatioships with the chemically induced carcinogenesis by MNU
Grantee:Sebastião Roberto Taboga
Support Opportunities: Regular Research Grants