The phosphate ester group in secondary metabolites

Author(s)

Della-Felice, Franco ; Bartolomeu, Aloisio de Andrade ; Pilli, Ronaldo Aloise

• Document type: Journal article
• Source: NATURAL PRODUCT REPORTS; v. 39, n. 5, p. 42-pg., 2022-04-14.

Abstract

Covering: 2000 to mid-2021 The phosphate ester is a versatile, widespread functional group involved in a plethora of biological activities. Its presence in secondary metabolites, however, is relatively rare compared to other functionalities and thus is part of a rather unexplored chemical space. Herein, the chemistry of secondary metabolites containing the phosphate ester group is discussed. The text emphasizes their structural diversity, biological and pharmacological profiles, and synthetic approaches employed in the phosphorylation step during total synthesis campaigns, covering the literature from 2000 to mid-2021. (AU)

• FAPESP's process: 16/12541-4 - A biomimetic approach to the total synthesis of Stemona alkaloids
• Grantee: Ronaldo Aloise Pilli
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/25474-8 - Synthesis and biological evualuation of Brevipolide A, Cryptomoskatone F1 and related compounds
• Grantee: Franco Della Felice
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 19/13104-5 - Planning and synthesis of inhibitors based on biological targets: the case of neglected kinases
• Grantee: Ronaldo Aloise Pilli
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
• Grantee: Licio Augusto Velloso
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 20/07991-6 - Preparation and biological evaluation of phosphoryl and phosphonyl derivatives of goniothalamin and piplartine
• Grantee: Aloisio de Andrade Bartolomeu
• Support Opportunities: Scholarships in Brazil - Post-Doctoral