| Full text | |
| Author(s): |
Kimura, Louise F.
;
Novaes, Leonardo S.
;
Picolo, Gisele
;
Munhoz, Carolina D.
;
Cheung, Chi W.
;
Camarini, Rosana
Total Authors: 6
|
| Document type: | Journal article |
| Source: | British Journal of Pharmacology; v. 179, n. 8, p. 21-pg., 2021-07-01. |
| Abstract | |
Depression and anxiety commonly occur in chronic pain states and the coexistence of these diseases worsens outcomes for both disorders and may reduce treatment adherence and response. Despite the advances in the knowledge of chronic pain mechanisms, pharmacological treatment is still unsatisfactory. Research based on exposure to environmental enrichment is currently under investigation and seems to offer a promising low-cost strategy with no side effects. In this review, we discuss the role of inflammation as a major biological substrate and aetiological factor of chronic pain and depression/anxiety and report a collection of preclinical evidence of the effects and mechanisms of environmental enrichment. As microglia participates in the development of both conditions, we also discuss microglia as a potential target underlying the beneficial actions of environmental enrichment in chronic pain and comorbid depression/anxiety. We also discuss how alternative interventions under clinical guidelines, such as environmental enrichment, may improve treatment compliance and patient outcomes. (AU) | |
| FAPESP's process: | 19/05882-8 - The role of crotalphine in the primary cilium dynamics of primary afferent neurons: novel insights for the study of analgesic compounds |
| Grantee: | Louise Faggionato Kimura Vieira |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/05038-0 - Effect of environmental enrichment on resilience to chronic unpredictable stress: epigenetic regulation of the BDNF gene and consequences on ethanol consumption |
| Grantee: | Rosana Camarini |
| Support Opportunities: | Regular Research Grants |