Partial efficacy of a Brazilian coralsnake antivenom and varespladib in neutralizing distinct toxic effects induced by sublethal Micrurus dumerilii carinicauda envenoming in rats
| Full text | |
| Author(s): Show less - |
Silva-Carvalho, Rosimeire
;
Gaspar, Matheus Z.
;
Quadros, Luiz H. B.
;
Lobo, Luis G. G.
;
Santar, Cecilia L.
;
Silva, Elisangela O.
;
Gerez, Juliana R.
;
Silva Jr, Nelson J.
;
Hyslop, Stephen
;
Lomonte, Bruno
;
Floriano, Rafael S.
Total Authors: 11
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| Document type: | Journal article |
| Source: | Toxicon; v. 213, p. 6-pg., 2022-07-15. |
| Abstract | |
In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor - VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations. (AU) | |
| FAPESP's process: | 20/14191-6 - Potential action of the phospholipase A2 inhibitor varespladib (LY-315920) on the systemic aspects of the envenomation by Micrurus corallinus coralsnake in rats |
| Grantee: | Matheus Zanutto Gaspar |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 20/04287-6 - Structural and pharmacological characterization of toxins isolated from Bothrops bilineatus smaragdinus (forest viper) venom with potential modulatory activity of the motor synaptic release and cardiovascular functions |
| Grantee: | Rafael Stuani Floriano |
| Support Opportunities: | BIOTA-FAPESP Program - Regular Research Grants |