Partial efficacy of a Brazilian coralsnake antivenom and varespladib in neutralizing distinct toxic effects induced by sublethal Micrurus dumerilii carinicauda envenoming in rats

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Silva-Carvalho, Rosimeire ; Gaspar, Matheus Z. ; Quadros, Luiz H. B. ; Lobo, Luis G. G. ; Santar, Cecilia L. ; Silva, Elisangela O. ; Gerez, Juliana R. ; Silva Jr, Nelson J. ; Hyslop, Stephen ; Lomonte, Bruno ; Floriano, Rafael S.

• Document type: Journal article
• Source: Toxicon; v. 213, p. 6-pg., 2022-07-15.

Abstract

In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor - VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations. (AU)

• FAPESP's process: 20/14191-6 - Potential action of the phospholipase A2 inhibitor varespladib (LY-315920) on the systemic aspects of the envenomation by Micrurus corallinus coralsnake in rats
• Grantee: Matheus Zanutto Gaspar
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 20/04287-6 - Structural and pharmacological characterization of toxins isolated from Bothrops bilineatus smaragdinus (forest viper) venom with potential modulatory activity of the motor synaptic release and cardiovascular functions
• Grantee: Rafael Stuani Floriano
• Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants