The gut-brain axis and sodium appetite: Can inflammation-related signaling influence the control of sodium intake

Author(s)

Freitas, Flavio Eduardo Dias Araujo ; Batista, Marcos Adriano Carlos ; Braga, Daiane Cristina de Assis ; de Oliveira, Lisandra Brandino ; Antunes, Vagner Roberto ; Cardoso, Leonardo Maximo

• Document type: Journal article
• Source: APPETITE; v. 175, p. 8-pg., 2022-08-01.

Abstract

Sodium is the main cation present in the extracellular fluid. Sodium and water content in the body are responsible for volume and osmotic homeostasis through mechanisms involving sodium and water excretion and intake. When body sodium content decreases below the homeostatic threshold, a condition termed sodium deficiency, highly motivated sodium seeking, and intake occurs. This is termed sodium appetite. Classically, sodium and water intakes are controlled by a number of neuroendocrine mechanisms that include signaling molecules from the renin-angiotensin-aldosterone system acting in the central nervous system (CNS). However, recent findings have shown that sodium and water intakes can also be influenced by inflammatory agents and mediators acting in the CNS. For instance, central infusion of IL-1 beta or TNF-alpha can directly affect sodium and water consumption in animal models. Some dietary conditions, such as high salt intake, have been shown to change the intestinal microbiome composition, stimulating the immune branch of the gut-brain axis through the production of inflammatory cytokines, such as IL-17, which can stimulate the brain immune system. In this review, we address the latest findings supporting the hypothesis that immune signaling in the brain could produce a reduction in thirst and sodium appetite and, therefore, contribute to sodium intake control. (AU)

• FAPESP's process: 19/19894-8 - Neuroanatomical and functional identification of the purinergic signaling in hypothalamic nuclei involved in the control of body fluids and salt-induced hypertension
• Grantee: Vagner Roberto Antunes
• Support Opportunities: Regular Research Grants