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Physical Exercise and Liver Autophagy: Potential Roles of IL-6 and Irisin

Full text
Author(s):
Pinto, Ana P. ; Ropelle, Eduardo R. ; Quadrilatero, Joe ; da Silva, Adelino S. R.
Total Authors: 4
Document type: Journal article
Source: EXERCISE AND SPORT SCIENCES REVIEWS; v. 50, n. 2, p. 8-pg., 2022-04-01.
Abstract

Autophagic dysregulation contributes to liver diseases. Although some investigations have examined the effects of endurance and resistance exercise on autophagy activation, potential myokines responsible for skeletal muscle-liver crosstalk are still unknown. Based on experimental studies and bioinformatics, we hypothesized that interleukin 6 (IL-6) and irisin might be key players in the contraction-induced release of molecules that regulate liver autophagic responses. (AU)

FAPESP's process: 17/19869-8 - Molecular mechanisms related to increased hepatic fat content in response to excessive physical exercise
Grantee:Ana Paula Pinto
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/15428-2 - Role of autophagy in muscle stem cell differentiation
Grantee:Ana Paula Pinto
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 19/00137-2 - Effects of physical exercise on the autophagy pathway
Grantee:Adelino Sanchez Ramos da Silva
Support Opportunities: Regular Research Grants