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Inadvertent Selection of a Pathogenic Fungus Highlights Areas of Concern in Human Clinical Practices

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Author(s):
Eagan, Justin L. ; Steffan, Breanne N. ; Ortiz, Sebastien C. ; Drott, Milton T. ; Goldman, Gustavo H. ; Hull, Christina M. ; Keller, Nancy P. ; Bastos, Rafael W.
Total Authors: 8
Document type: Journal article
Source: JOURNAL OF FUNGI; v. 8, n. 2, p. 11-pg., 2022-02-01.
Abstract

In studying the development of tolerance to common hospital cleaners (Oxivir(R) and CaviCide (TM)) in clinical isolate stocks of the emerging, multidrug-resistant yeast pathogen Candida auris, we selected for a cleaner-tolerant subpopulation of a more common nosocomial pathogen, Candida glabrata. Through the purification of each species and subsequent competition and other analyses, we determined that C. glabrata is capable of readily dominating mixed populations of C. auris and C. glabrata when exposed to hospital cleaners. This result suggests that exposure to antimicrobial compounds can preferentially select for low-level, stress-tolerant fungal pathogens. These findings indicate that clinical disinfection practices could contribute to the selection of tolerant, pathogenic microbes that persist within healthcare settings. (AU)

FAPESP's process: 16/07870-9 - The influence of mitogen activated protein kinases (MAPK) on the expression of genetic determinants important for Aspergillus fumigatus virulence
Grantee:Gustavo Henrique Goldman
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/19821-5 - Molecular, phenotypic and immune response characterization of clinical isolates of Aspergillus nidulans
Grantee:Rafael Wesley Bastos
Support Opportunities: Scholarships in Brazil - Post-Doctoral