High Definition tDCS Effect on Postural Control in Healthy Individuals: Entropy Analysis of a Crossover Clinical Trial

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Favoretto, Diandra B. ; Bergonzoni, Eduardo ; Carvalho Nascimento, Diego ; Louzada, Francisco ; Lemos, Tenysson W. ; Batistela, Rosangela A. ; Moraes, Renato ; Leite, Joao P. ; Rimoli, Brunna P. ; Edwards, Dylan J. ; Edwards, Taiza G. S.

• Document type: Journal article
• Source: APPLIED SCIENCES-BASEL; v. 12, n. 5, p. 14-pg., 2022-03-01.

Abstract

Objective: Converging evidence supporting an effect of transcranial direct current stimulation (tDCS) on postural control and human verticality perception highlights this strategy as promising for post-stroke rehabilitation. We have previously demonstrated polarity-dependent effects of high-definition tDCS (HD-tDCS) on weight-bearing asymmetry. However, there is no investigation regarding the time-course of effects on postural control induced by HD-tDCS protocols. Thus, we performed a nonlinear time series analysis focusing on the entropy of the ground reaction force as a secondary investigation of our randomized, double-blind, placebo-controlled, crossover clinical trial. Materials and Methods: Twenty healthy right-handed young adults received the following conditions (random order, separate days); anode center HD-tDCS, cathode center HD-tDCS or sham HD-tDCS at 1, 2, and 3 mA over the right temporo-parietal junction (TPJ). Using summarized time series of transfer entropy, we evaluated the exchanging information (causal direction) between both force plates and compared the dose-response across the healthy subjects with a Generalized Linear Hierarchical/Mixed Model (GLMM). Results: We found significant variation during the dynamic information flow (p < 0.001) among the dominant bodyside (and across time). A greater force transfer entropy was observed from the right to the left side during the cathode-center HD-tDCS up to 2 mA, with a causal relationship in the information flow (equilibrium force transfer) from right to left that decreased over time. Conclusions: HD-tDCS intervention induced a dynamic influence over time on postural control entropy. Right hemisphere TPJ stimulation using cathode-center HD-tDCS can induce an asymmetry of body weight distribution towards the ipsilateral side of stimulation. These results support the clinical potential of HD-tDCS for post-stroke rehabilitation. (AU)

• FAPESP's process: 20/09174-5 - Recommendation system of interest items for BeeNet users
• Grantee: Diego Carvalho do Nascimento
• Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
• FAPESP's process: 13/07375-0 - CeMEAI - Center for Mathematical Sciences Applied to Industry
• Grantee: Francisco Louzada Neto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC