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Contrast agent-free state-of-the-art magnetic resonance imaging on cerebral small vessel disease - Part 2: Diffusion tensor imaging and functional magnetic resonance imaging

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Author(s):
Rodrigues da Silva, Pedro Henrique ; Paschoal, Andre Monteiro ; Secchinatto, Kaio Felippe ; Zanon Zotin, Maria Clara ; dos Santos, Antonio Carlos ; Viswanathan, Anand ; Pontes-Neto, Octavio M. ; Leoni, Renata Ferranti
Total Authors: 8
Document type: Journal article
Source: NMR in Biomedicine; v. 35, n. 8, p. 17-pg., 2022-05-06.
Abstract

Cerebral small vessel disease (cSVD) has been widely studied using conventional magnetic resonance imaging (MRI) methods, although the association between MRI findings and clinical features of cSVD is not always concordant. We assessed the additional contribution of contrast agent-free, state-of-the-art MRI techniques, particularly diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI), to understand brain damage and structural and functional connectivity impairment related to cSVD. We performed a review following the PICOS worksheet and Search Strategy, including 152 original papers in English, published from 2000 to 2022. For each MRI method, we extracted information about their contributions regarding the origins, pathology, markers, and clinical outcomes in cSVD. In general, DTI studies have shown that changes in mean, radial, and axial diffusivity measures are related to the presence of cSVD. In addition to the classical deficit in executive functions and processing speed, fMRI studies indicate connectivity dysfunctions in other domains, such as sensorimotor, memory, and attention. Neuroimaging metrics have been correlated with the diagnosis, prognosis, and rehabilitation of patients with cSVD. In short, the application of contrast agent-free, state-of-the-art MRI techniques has provided a complete picture of cSVD markers and tools to explore questions that have not yet been clarified about this clinical condition. Longitudinal studies are desirable to look for causal relationships between image biomarkers and clinical outcomes. (AU)

FAPESP's process: 17/22212-0 - Structural and functional brain networks: from connections to cognition a study applied to Cerebral Small Vessel Disease
Grantee:Pedro Henrique Rodrigues da Silva
Support Opportunities: Scholarships in Brazil - Doctorate