Structural and functional brain networks: from connections to cognition a study applied to Cerebral Small Vessel Disease

• Grant number: 17/22212-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: January 01, 2019
• End date: January 31, 2022
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: Renata Ferranti Leoni
• Grantee: Pedro Henrique Rodrigues da Silva
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

In the human brain, neuronal interactions represent the dynamics of a fixed structural connectivity that underlies cognition and behavior. The divergence between (dynamic) functional connectivity and (fixed) structural connectivity is perhaps the most intriguing of the brain and calls for intensive research. We can better understand the functioning of the brain and its relation to cognition studying the dynamics and self-organization of functional networks. We will try to answer these questions by testing whether the pattern in resting-state functional networks can predict cognitive task activations in extended regions and how structural connectivity is related to it. In this context, we will evaluate functional localization and integration in response to the execution of a cognitive task, the Symbol Digit Modalities Test (SDMT), which evaluates the Information Processing Speed (IPS), adapted to the Magnetic Resonance Imaging (MRI) environment. More specifically, we will examine how regions within the brain network interact with each other studying the effective connectivity, defined as how one region influences or causes activity in another during the neural process. For purposes of clinical application, patients with Cerebral Small Vessel Disease (CSVD) are of great interest, given the impact on global public health, open questions about the structural and functional damages that the disease causes and the high incidence of cognitive deficit in processing speed. Therefore, with the development of the present work, we intend to determine a structured process to investigate the dynamics of functional networks, its relationship with the structural networks and the cognitive performance of IPS in healthy individuals and in a clinical group with CSVD. We will use empirical data obtained with acquisition of MR images and neuropsychological evaluation. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PASCHOAL, ANDRE MONTEIRO; SECCHINATTO, KAIO FELIPPE; DA SILVA, PEDRO HENRIQUE RODRIGUES; ZOTIN, MARIA CLARA ZANON; DOS SANTOS, ANTONIO CARLOS; VISWANATHAN, ANAND; PONTES-NETO, OCTAVIO M.; LEONI, RENATA FERRANTI. Contrast-agent-free state-of-the-art MRI on cerebral small vessel disease-part 1. ASL, IVIM, and CVR. NMR in Biomedicine, v. 35, n. 8, p. 11-pg., 2022-05-01. (17/22212-0)

RODRIGUES DA SILVA, PEDRO HENRIQUE; PASCHOAL, ANDRE MONTEIRO; SECCHINATTO, KAIO FELIPPE; ZANON ZOTIN, MARIA CLARA; DOS SANTOS, ANTONIO CARLOS; VISWANATHAN, ANAND; PONTES-NETO, OCTAVIO M.; LEONI, RENATA FERRANTI. Contrast agent-free state-of-the-art magnetic resonance imaging on cerebral small vessel disease - Part 2: Diffusion tensor imaging and functional magnetic resonance imaging. NMR in Biomedicine, v. 35, n. 8, p. 17-pg., 2022-05-06. (17/22212-0)

DA SILVA, PEDRO HENRIQUE RODRIGUES; RONDINONI, CARLO; LEONI, RENATA F.. Non-classical behavior of the default mode network regions during an information processing task. Brain Structure & Function, v. 225, n. 8, p. 10-pg., 2020-09-16. (17/22212-0)

DA SILVA, PEDRO HENRIQUE RODRIGUES; DE LEEUW, FRANK-ERIK; ZOTIN, MARIA CLARA ZANON; NETO, OCTAVIO MARQUES PONTES; LEONI, RENATA FERRANTI; TULADHAR, ANIL M.. Neural Substrates of Psychomotor Speed Deficits in Cerebral Small Vessel Disease: A Brain Disconnectome Mapping Study. BRAIN TOPOGRAPHY, v. 36, n. 4, p. 9-pg., 2023-05-08. (17/22212-0)

DA SILVA, PEDRO HENRIQUE RODRIGUES; DE LEEUW, FRANK-ERIK; ZOTIN, MARIA CLARA ZANON; NETO, OCTAVIO MARQUES PONTES; LEONI, RENATA FERRANTI; TULADHAR, ANIL M.. Cortical Thickness and Brain Connectivity Mediate the Relation Between White Matter Hyperintensity and Information Processing Speed in Cerebral Small Vessel Disease. BRAIN TOPOGRAPHY, v. 36, n. 4, p. 18-pg., 2023-06-05. (17/22212-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Pedro Henrique Rodrigues da. Brain structural and functional networks: from connections to cognition. A study applied to cerebral small vessel disease. 2022. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (PCARP/BC) Ribeirão Preto.