| Full text | |
| Author(s): |
Serafim, Marcela Sayegh
;
Rodrigues, Debora Munhoz
;
Ribeiro, Victor Pena
;
Ccana-Ccapatinta, Gari Vidal
;
Groppo, Milton
;
Gomes Martins, Carlos Henrique
;
Ambrosio, Sergio Ricardo
;
Kenupp Bastos, A. N. D. Jairo
Total Authors: 8
|
| Document type: | Journal article |
| Source: | NATURAL PRODUCT RESEARCH; v. N/A, p. 10-pg., 2022-04-12. |
| Abstract | |
Fungal resistance to different therapeutic drugs has become a growing challenge. This crucial health problem requires new effective drug alternatives. Herein, we report the study of Eucalyptus botryoides' resin used in folk medicine as antimicrobial. Thus, E. botryoides' resin was extracted with aqueous-ethanol and fractionated using Sephadex chromatography, furnishing its major compounds. The crude extracts and the isolated compounds were evaluated for their in vitro antimicrobial activity against bacteria and yeasts. The crude extract displayed MIC of 25 mu g/mL against S. salivarius, and for C. albicans, C. glabrata, and C. tropicalis the MIC were between 2.9 and 5.9 mu g/mL. The 7-O-Methyl-aromadendrin was the most effective against C. glabrata and C. krusei (MIC = 1.6 mu g/mL). 2-O-Galloyl-1,6-O-di-trans-p-coumaroyl-beta-D-glycopyranoside, first time reported, showed MIC of 3.1 mu g/mL against C. glabrata and C. krusei. Overall, this work gave promising results, indicating that Eucalyptus botryoides' resin and its compounds have the potential for developing anti-yeast products. (AU) | |
| FAPESP's process: | 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector |
| Grantee: | Jairo Kenupp Bastos |
| Support Opportunities: | Research Projects - Thematic Grants |