| Full text | |
| Author(s): |
de Albuquerque Biasotti, Gabriel Gustavo
;
Prospero, Andre Goncalves
;
Tacconi Alvarez, Marcelo Dante
;
Liebl, Maik
;
Pinto, Leonardo Antonio
;
Soares, Guilherme Augusto
;
Bakuzis, Andris Figueiroa
;
Baffa, Oswaldo
;
Wiekhorst, Frank
;
de Arruda Miranda, Jose Ricardo
Total Authors: 10
|
| Document type: | Journal article |
| Source: | SENSORS; v. 21, n. 21, p. 18-pg., 2021-11-01. |
| Abstract | |
The use of magnetic nanoparticles (MNPs) in biomedical applications requires the quantitative knowledge of their quantitative distribution within the body. AC Biosusceptometry (ACB) is a biomagnetic technique recently employed to detect MNPs in vivo by measuring the MNPs response when exposed to an alternate magnetic field. The ACB technique presents some interesting characteristics: non-invasiveness, low operational cost, high portability, and no need for magnetic shielding. ACB conventional methods until now provided only qualitative information about the MNPs' mapping in small animals. We present a theoretical model and experimentally demonstrate the feasibility of ACB reconstructing 2D quantitative images of MNPs' distributions. We employed an ACB single-channel scanning approach, measuring at 361 sensor positions, to reconstruct MNPs' spatial distributions. For this, we established a discrete forward problem and solved the ACB system's inverse problem. Thus, we were able to determine the positions and quantities of MNPs in a field of view of 5 x 5 x 1 cm(3) with good precision and accuracy. The results show the ACB system's capabilities to reconstruct the quantitative spatial distribution of MNPs with a spatial resolution better than 1 cm, and a sensitivity of 1.17 mg of MNPs fixed in gypsum. These results show the system's potential for biomedical application of MNPs in several studies, for example, electrochemical-functionalized MNPs for cancer cell targeting, quantitative sensing, and possibly in vivo imaging. (AU) | |
| FAPESP's process: | 13/07699-0 - Research, Innovation and Dissemination Center for Neuromathematics - NeuroMat |
| Grantee: | Oswaldo Baffa Filho |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |