| Full text | |
| Author(s): |
Marco A. Lima-Noronha
[1]
;
Douglas L. H. Fonseca
[2]
;
Renatta S. Oliveira
[3]
;
Rúbia R. Freitas
[4]
;
Jung H. Park
[5]
;
Rodrigo S. Galhardo
[6]
Total Authors: 6
|
| Affiliation: | [1] Universidade de São Paulo. Instituro de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[2] Universidade de São Paulo. Instituro de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[3] Universidade de São Paulo. Instituro de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[4] Universidade de São Paulo. Instituro de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[5] Universidade de São Paulo. Instituro de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[6] Universidade de São Paulo. Instituro de Ciências Biomédicas. Departamento de Microbiologia - Brasil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | GENETICS AND MOLECULAR BIOLOGY; v. 45, n. 3 2022-10-10. |
| Abstract | |
Abstract The term “SOS response” was first coined by Radman in 1974, in an intellectual effort to put together the data suggestive of a concerted gene expression program in cells undergoing DNA damage. A large amount of information about this cellular response has been collected over the following decades. In this review, we will focus on a few of the relevant aspects about the SOS response: its mechanism of control and the stressors which activate it, the diversity of regulated genes in different species, its role in mutagenesis and evolution including the development of antimicrobial resistance, and its relationship with mobile genetic elements. (AU) | |
| FAPESP's process: | 20/00535-5 - Influence of integrative and conjugative elements (ices) from the SXT/R391 family on physiological and pathogenic aspects of Proteus mirabilis |
| Grantee: | Douglas Lyra de Holanda Fonseca |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 20/12744-8 - Genomic and genetic analysis of SOS response induction in Pseudomonas aeruginosa |
| Grantee: | Renatta Santos de Oliveira |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 19/19435-3 - The role of DNA damage and mitochondrial function in vascular, immune and neurological ageing (DNA MoVINg) |
| Grantee: | Carlos Frederico Martins Menck |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 21/15170-5 - Conjugative and integrative elements of the SXT/R391 family in Proteus mirabilis |
| Grantee: | Rodrigo da Silva Galhardo |
| Support Opportunities: | Regular Research Grants |