| Full text | |
| Author(s): |
Lorenzo Fernandes Moça Trevisani
[1]
;
Isabelle Fernandes Kulcsar
[2]
;
Ana Kober Nogueira Leite
[3]
;
Marco Aurélio Vamondes Kulcsar
[4]
;
Graziele Aparecida Simões Lima
[5]
;
Rogerio Aparecido Dedivitis
[6]
;
Luiz Paulo Kowalski
[7]
;
Leandro Luongo Matos
Total Authors: 8
|
| Affiliation: | [1] Universidade de São Paulo. Faculdade de Medicina. Programa de Pós-Graduacão em Anestesiologia, Ciências Cirúrgicas e Medicina Perioperatória - Brasil
[2] Universidade Anhembi Morumbi - Brasil
[3] Universidade de São Paulo. Faculdade de Medicina. Instituto do Câncer do Estado de São Paulo (Icesp) - Brasil
[4] Universidade de São Paulo. Faculdade de Medicina. Instituto do Câncer do Estado de São Paulo (Icesp) - Brasil
[5] Universidade de São Paulo. Faculdade de Medicina. Instituto do Câncer do Estado de São Paulo (Icesp) - Brasil
[6] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[7] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Otorhinolaryngology; v. 88, p. S89-S97, 2023-01-16. |
| Abstract | |
Abstract Objective: The aim of the present study was to analyze the prognostic relationship of weight loss and preoperative hematological indexes in patients surgically treated for pT4a squamous cell carcinoma of the oral cavity. Methods: A retrospective cohort study. Results: Percent weight loss greater than 10% was identified in 49 patients (28.2%), and any weight loss in relation to the usual weight occurred in 140 patients (78.7%). Percent weight loss greater than 10% (HR = 1.679), Red cell distribution width (RDW) values greater than 14.3% (HR = 2.210) and extracapsular spread (HR = 1.677) were independent variables associated with risk of death. Conclusion: Patients with advanced squamous cell carcinoma of the oral cavity present significant weight loss and as significantly immunocompromised. Increased values of RDW and higher percentages of weight loss in relation to the individual’s usual weight, together with extracapsular spread of metastatic lymph nodes, were risk factors for lower survival, regardless of other clinical and anatomopathological characteristics. Level of evidence: 3. (AU) | |
| FAPESP's process: | 16/01740-6 - Proteoglycans profile and micro-RNA expression associated to tumor invasion and prognosis in oral cavity squamous cell carcinoma |
| Grantee: | Leandro Luongo de Matos |
| Support Opportunities: | Regular Research Grants |