| Full text | |
| Author(s): |
Faria, Alessandra V. S.
;
Andrade, Sheila S.
;
Peppelenbosch, Maikel P.
;
Ferreira-Halder, Carmen V.
;
Fuhler, Gwenny M.
Total Authors: 5
|
| Document type: | Journal article |
| Source: | CANCER AND METASTASIS REVIEWS; v. 39, n. 4, p. 17-pg., 2020-09-01. |
| Abstract | |
Platelets control hemostasis and play a key role in inflammation and immunity. However, platelet function may change during aging, and a role for these versatile cells in many age-related pathological processes is emerging. In addition to a well-known role in cardiovascular disease, platelet activity is now thought to contribute to cancer cell metastasis and tumor-associated venous thromboembolism (VTE) development. Worldwide, the great majority of all patients with cardiovascular disease and some with cancer receive anti-platelet therapy to reduce the risk of thrombosis. However, not only do thrombotic diseases remain a leading cause of morbidity and mortality, cancer, especially metastasis, is still the second cause of death worldwide. Understanding how platelets change during aging and how they may contribute to aging-related diseases such as cancer may contribute to steps taken along the road towards a "healthy aging" strategy. Here, we review the changes that occur in platelets during aging, and investigate how these versatile blood components contribute to cancer progression. (AU) | |
| FAPESP's process: | 16/14459-3 - Human platelet lysate: from discard to value products in cell therapy and advanced cell-based medicine |
| Grantee: | Sheila Siqueira Andrade |
| Support Opportunities: | Research Grants - Innovative Research in Small Business - PIPE |
| FAPESP's process: | 17/08119-8 - Hematogenous tumor metastasis in colon rectal cancer cells: influence of LMWPTP and 3-bromopyruvate |
| Grantee: | Alessandra Valéria de Sousa Faria |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/00736-0 - MicroRNAs in stool and platelets biology from gastroenterology cancer patient samples that correlate with ACP1 protein tyrosine phosphatase: colorectal cancer screening |
| Grantee: | Alessandra Valéria de Sousa Faria |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 17/26317-1 - InGrowth, biomimetic product developed by platelet bioactivation platform: applications in the veterinary and research and development areas |
| Grantee: | Sheila Siqueira Andrade |
| Support Opportunities: | Research Grants - Innovative Research in Small Business - PIPE |
| FAPESP's process: | 15/20412-7 - Low molecular weight protein tyrosine phosphatase in colorectal cancer: from the bench to product generation |
| Grantee: | Carmen Veríssima Ferreira |
| Support Opportunities: | Research Projects - Thematic Grants |