Arboviral Infections in Neurological Disorders in Hospitalized Patients in Sao Jose do Rio Preto, Sao Paulo, Brazil

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Milhim, Bruno H. G. A. ; da Rocha, Leonardo C. ; Terzian, Ana C. B. ; Mazaro, Carolina C. P. ; Augusto, Marcos T. ; Luchs, Adriana ; Zini, Nathalia ; Sacchetto, Livia ; dos Santos, Barbara F. ; Garcia, Pedro H. C. ; Rocha, Rodrigo S. ; Liso, Elisabete ; Brienze, Vania M. S. ; da Silva, Gislaine C. D. ; Vasilakis, Nikos ; Estofolete, Cassia F. ; Nogueira, Mauricio L.

• Document type: Journal article
• Source: Viruses-Basel; v. 14, n. 7, p. 12-pg., 2022-07-01.

Abstract

Arbovirus infections are increasingly important causes of disease, whose spectrum of neurological manifestations are not fully known. This study sought to retrospectively assess the incidence of arboviruses in cerebrospinal fluid samples of patients with neurological symptoms to inform diagnosis of central and peripheral nervous system disorders. A total of 255 cerebrospinal fluid (CSF) samples collected from January 2016 to December 2017 were tested for dengue virus (DENV 1-4), Zika virus (ZIKV), and Chikungunya virus (CHIKV) in addition to other neurotropic arboviruses of interest, using genetic and serologic assays. Of the 255 CSF samples analyzed, 3.53% (09/255) were positive for arboviruses presenting mainly as meningitis, encephalitis, and cerebrovascular events, of which ZIKV was detected in 2.74% (7/255), DENV in 0.78% (2/255), in addition to an identified ILHV infection that was described previously. All the cases were detected in adults aged 18 to 74 years old. Our findings highlight the scientific and clinical importance of neurological syndromes associated with arboviruses and demonstrate the relevance of specific laboratory methods to achieve accurate diagnoses as well as highlight the true dimension of these diseases to ultimately improve public health planning and medical case management. (AU)

• FAPESP's process: 15/12295-0 - Diagnostic of Brazilian and emergent arboviruses in patients and mosquitoes from two distinct regions in Brazil
• Grantee: Ana Carolina Bernardes Terzian
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018
• Grantee: Maurício Lacerda Nogueira
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 16/15021-1 - Clinical-epidemiological study of a cohort of Zika infected pregnant women in São José do Rio Preto, SP
• Grantee: Maurício Lacerda Nogueira
• Support Opportunities: Research Grants - Research in Public Policies for the National Health Care System (PP-SUS)