Diabetes and bone

Author(s)

de Araujo, Iona Mizumukai ; Mascarenhas Moreira, Mariana Lima ; Albuquerque de Paula, Francisco Jose

• Document type: Journal article
• Source: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 66, n. 5, p. 9-pg., 2022-09-01.

Abstract

Globally, one in 11 adults has diabetes mellitus of which 90% have type 2 diabetes. The numbers for osteoporosis are no less staggering: 1 in 3 women has a fracture after menopause, and the same is true for 1 in 5 men after the age of 50 years. Aging is associated with several physiological changes that cause insulin resistance and impaired insulin secretion, which in turn lead to hyperglycemia. The negative balance between bone resorption and formation is a natural process that appears after the fourth decade of life and lasts for the following decades, eroding the bone structure and increasing the risk of fractures. Not incidentally, it has been acknowledged that diabetes mellitus, regardless of whether type 1 or 2, is associated with an increased risk of fracture. The nuances that differentiate bone damage in the two main forms of diabetes are part of the intrinsic heterogeneity of diabetes, which is enhanced when associated with a condition as complex as osteoporosis. This narrative review addresses the main parameters related to the increased risk of fractures in individuals with diabetes, and the mutual factors affecting the treatment of diabetes mellitus and osteoporosis. Arch Endocrinol Metab. 2022;66(5):633-41 (AU)

• FAPESP's process: 18/18071-5 - Hydroelectrolytic and energy homeostasis: from cellular metabolism to endocrine systems in different phases of development
• Grantee: Lucila Leico Kagohara Elias
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 21/03152-2 - Interaction between fat, muscle, and bone tissues in anorexia nervosa
• Grantee: Iana Mizumukai de Araujo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral