CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer

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Author(s):	Almeida, Renata Sanches ; Wisnieski, Fernanda ; Real Karia, Bruno Takao ; Cardoso Smith, Marilia Arruda Total Authors: 4
Document type:	Journal article
Source:	GENES; v. 13, n. 11, p. 13-pg., 2022-11-01.
Abstract
Gastric cancer is the subject of clinical and basic studies due to its high incidence and mortality rates worldwide. Due to the diagnosis occurring in advanced stages and the classic treatment methodologies such as gastrectomy and chemotherapy, they are extremely aggressive and limit the quality of life of these patients. CRISPR/Cas9 is a tool that allows gene editing and has been used to explore the functions of genes related to gastric cancer, in addition to being used in the treatment of this neoplasm, greatly increasing our understanding of cancer genomics. In this mini-review, we seek the current status of the CRISPR/Cas9 gene-editing technology in gastric cancer research and clinical research. (AU)

FAPESP's process:	16/25562-0 - Gastric cancer molecular and functional approaches in the Brazilian population
Grantee:	Marilia de Arruda Cardoso Smith
Support Opportunities:	Research Projects - Thematic Grants


FAPESP's process:	19/20592-6 - Investigation of miRNAs differentialy expressed in plasma of patients with gastric adenocarcinoma.
Grantee:	Bruno Takao Real Karia
Support Opportunities:	Scholarships in Brazil - Post-Doctoral