| Full text | |
| Author(s): |
Bueno, Maura Lima Pereira
;
Saad, Sara Teresinha Olalla
;
Roversi, Fernanda Marconi
Total Authors: 3
|
| Document type: | Journal article |
| Source: | BIOMEDICINE & PHARMACOTHERAPY; v. 155, p. 18-pg., 2022-10-18. |
| Abstract | |
The investigation of tumor microenvironment (TME) is essential to better characterize the complex cellular crosstalk and to identify important immunological phenotypes and biomarkers. The niche is a crucial contributor to neoplasm initiation, maintenance and progression. Therefore, a deeper analysis of tumor surroundings could improve cancer diagnosis, prognosis and assertive treatment. Thus, the WNT family exerts a critical action in tumorigenesis of different types of neoplasms due to dysregulations in the TME. WNT5A, an evolutionary WNT member, is involved in several cellular and physiopathological processes, in addition to tissue homeostasis. The WNT5A protein exerts paradoxical effects while acting as both an oncogene or tumor suppressor by regulating several non-canonical signaling pathways, and consequently interfering in cell growth, cytoskeletal remodeling, migration and invasiveness. This review focuses on a thorough characterization of the role of WNT5A in neoplastic transformation and progression, which may help to understand the prognostic potentiality of WNT5A and its features as a therapeutic target in several cancers. Additionally, we herein summarized novel findings on the mechanisms by which WNT5A might favor tumorigenesis or suppression of cancer progression and discussed the recently developed treatment strategies using WNT5A as a protagonist. (AU) | |
| FAPESP's process: | 19/25247-5 - Study of inhibitory and antitumor activity of natural substance-associated MAPK and WNT inhibitors in in vitro models |
| Grantee: | Maura Lima Pereira Bueno |
| Support Opportunities: | Scholarships in Brazil - Technical Training Program - Technical Training |
| FAPESP's process: | 17/21801-2 - Predictors of severity and new treatments for bone marrow neoplasias |
| Grantee: | Sara Teresinha Olalla Saad |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 21/05320-0 - Profile of Brazilian undergraduates who use electronic cigarettes: an epidemiological study on forbidden use |
| Grantee: | Gabriella dos Santos Maximino |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |