Does undiagnosed diabetes mitigate the association between diabetes and cognitive impairment? Findings from theELSI-Brazilstudy

Author(s)

Cochar-Soares, Natalia ; de Carvalho, Danilo H. T. ; de Andrade, Fabiola B. ; Castro-Costa, Erico ; de Oliveira, Cesar ; Lima-Costa, Maria F. ; Alexandre, Tiago da S.

• Document type: Journal article
• Source: JOURNAL OF DIABETES; v. 12, n. 11, p. 10-pg., 2020-07-22.

Abstract

Background Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment. However, most of the evidence has been based on self-reported T2DM, and undiagnosed diabetes has not been considered as a separate category. We aimed to examine the extent to which undiagnosed diabetes modifies the association between diabetes and cognitive impairment in a representative sample of Brazilian adults aged 50 years and older. Methods We analyzed baseline data from 1944 participants of the Brazilian Longitudinal Study of Aging (ELSI-Brazil) conducted from 2015 to 2016. Diabetes was evaluated based on self-reported doctor diagnosis and glycosylated hemoglobin levels. Participants were classified as diabetics (D), undiagnosed diabetics (UDD), or nondiabetics (ND). Cognitive function was assessed by word list learning and verbal fluency tests. Three multiple logistic regression models were used to evaluate the changes in the strength of the associations. Results Participants with diabetes had 49% greater odds of exhibiting impaired memory than nondiabetics (odds ratio [OR] = 1.49; 95% CI: 1.01-2.20). By combining UDD and ND, the association between diabetes and impaired memory was attenuated by 2.0%, losing its statistical significance (OR = 1.46; 95% CI: 0.98-2.17). By combining UDD and D, the association was attenuated by 7.4% (OR = 1.38; 95% CI: 1.01-1.90). No significant association was found between T2DM and impaired verbal fluency. Conclusion This study found an association between T2DM and impaired memory but not with impaired verbal fluency. When UDD individuals are considered diabetics, this association is attenuated; when UDD individuals are considered as ND, this association is attenuated to the extent that it loses its statistical significance, affecting thus the clinical interpretation. (AU)

• FAPESP's process: 18/13917-3 - Musculoskeletal aging: metabolic and functional repercussions and mortality risk in people aged 50 and older
• Grantee: Tiago da Silva Alexandre
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 17/22818-6 - The effect of undiagnosed diabetes on association between self-reported diabetes and two cognitive domains: language and memory in adults over 50 years old: ELSI study
• Grantee: Natália Cochar Soares
• Support Opportunities: Scholarships in Brazil - Scientific Initiation