Metabolomics Reveals a 26-Membered Macrolactone Produced by Endophytic Colletotrichum spp. from Alcatrazes Island, Brazil

Author(s):Show less -

Takaki, Mirelle ; Williams, David E. ; Freire, Vitor F. ; Sartori, Sergio B. ; Lira, Simone P. ; Bizarria Jr, Rodolfo ; Rodrigues, Andre ; da Costa, Danielle R. Goncalves ; Amorim, Marcelo R. . ; Ferreira, Antonio G. ; Andersen, Raymond J. ; Linington, Roger G. ; Berlinck, Roberto G. S.

• Document type: Journal article
• Source: ORGANIC LETTERS; v. N/A, p. 5-pg., 2022-12-15.

Abstract

Comparative metabolomics analysis of nonphytotoxic endo-phytic Colletotrichum spp. isolated from Anthur i u m alcatrazense endemic to Alcatrazes island (Brazil) and phytopathogenic Colletotrichum spp. isolated from the mainland of Brazil revealed significant differences in chemical composition. Examination of endophytic Colletotrichum spp. from Alcatrazes island led to the discovery of a 26-member macrolactone, colletotrichumolide (1), containing a phosphatidyl choline side chain. Further examination of the phytopathogenic strains from the mainland identified a family of phytopathogenic metabolites not present in the nonpathogenic island-derived strains, suggesting that geographical isolation could influence the secondary metabolism of fungal strains. (AU)

• FAPESP's process: 20/01229-5 - Bioactive metabolites of bacterial flora microorganisms from non-filtering marine animals
• Grantee: Marcelo Rodrigues de Amorim
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach
• Grantee: Roberto Gomes de Souza Berlinck
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
• FAPESP's process: 18/03679-8 - Use of statistical tools and molecular networking for the metabolomics analysis of Colletotrichum spp
• Grantee: Mirelle Takaki
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 15/14114-3 - Which metabolomics components influence the phytopathogenicity of Colletotrichum spp.?
• Grantee: Mirelle Takaki
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/17721-9 - The role of Chemistry in holobiont adaptation
• Grantee: Roberto Gomes de Souza Berlinck
• Support Opportunities: Research Projects - Thematic Grants