| Full text | |
| Author(s): |
Lima, Rafaely N.
;
Anjos, Charlene S.
;
Porto, Andre L. M.
Total Authors: 3
|
| Document type: | Journal article |
| Source: | MOLECULAR CATALYSIS; v. 530, p. 9-pg., 2022-08-26. |
| Abstract | |
In this study, 37 fatty acid amides were obtained by CAL-B (Novozym 435) in 2 h, with yields up to 91%. The (S)-mandelic acid amides (3a-3l, 14-91%), salicylic acid amides (3m-3y, 57-90%), and 3-(4-hydroxyphenyl) propanoic acid amides (3z-3ak, 17-70%) were efficiently synthetized using different fatty acids in an esterification reaction catalyzed by CAL-B. An one-pot procedure was developed, and the fatty acid amide 3m was obtained in 63% after two-steps. The same procedure was applied using coconut oil, a product rich in triglycerides containing C-12-C-16 carbon chains, and the fatty acid amide 3al was obtained with 60% yield. These results represent an important contribution to the biocatalytic synthesis of fatty acid amides for possible cosmetic and pharmacological applications. (AU) | |
| FAPESP's process: | 16/20155-7 - Biocatalytic reactions of aminolysis and kinetic resolution by lipases and biodegradation of agrochemicals by microorganisms |
| Grantee: | Andre Luiz Meleiro Porto |
| Support Opportunities: | Regular Research Grants |