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Design of new biocatalizers by surface modifications of post-immobilization lipases for application in xylose oleate synthesis

Grant number: 19/23908-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2020
Field of knowledge:Engineering - Chemical Engineering - Chemical Process Industries
Principal researcher:Paulo Waldir Tardioli
Grantee:Maria Carolina Pereira Gonçalves
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:16/10636-8 - From the cell factory to the Biodiesel-Bioethanol integrated biorefinery: a systems approach applied to complex problems in micro and macroscales, AP.BIOEN.TEM
Associated scholarship(s):21/06525-4 - Production and purification of mixed sugars for use in the synthesis of xylose fatty esters catalyzed by immobilized-stabilized derivatives of Candida antarctica lipase B, BE.EP.DR


Under the concept of biorefinery, the biotechnology industry has been seeking the use of abundant renewable raw materials in order to convert them into high value-added products, in addition to meeting the principles of sustainability and green chemistry. In this context, sugar fatty esters, non-ionic surfactants, of low toxicity and biodegradable, appear like some of these products of economic value, are widely used in different industrial sectors. The synthesis of these compounds is usually performed by the chemical route, which requires a high energy demand and presents low selectivity, making the separation/purification steps of the products expensive. As an alternative to this method, it is proposed the use of an enzymatic route, with the possibility of obtaining a totally renewable product. In this project, it will be used lipases B from Candida antarctica (CALB) as biocatalysts, as well as xylose and oleic acid as substrates, aiming at the production of xylose fatty esters. The lipase will be immobilized on hydrophobic supports and treated with surface modifying agents in order to evaluate the effect of these modifications on the catalytic properties and stability of the new biocatalysts. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROMANELLI, JOAO PAULO; GONCALVES, MARIA CAROLINA PEREIRA; DE ABREU PESTANA, LUIS FERNANDO; SOARES, JESSICA AKEMI HITAKA; BOSCHI, RAQUEL STUCCHI; ANDRADE, DANIEL FERNANDES. Four challenges when conducting bibliometric reviews and how to deal with them. Environmental Science and Pollution Research, v. 28, n. 43 SEP 2021. Web of Science Citations: 0.
GONCALVES, MARIA CAROLINA PEREIRA; ROMANELLI, JOAO PAULO; GUIMARAES, JOSE RENATO; VIEIRA, ANA CAROLINA; DE AZEVEDO, BRUNA PEREIRA; TARDIOLI, PAULO WALDIR. Reviewing research on the synthesis of CALB-catalyzed sugar esters incorporating systematic mapping principles. CRITICAL REVIEWS IN BIOTECHNOLOGY, v. 41, n. 6, p. 865-878, AUG 18 2021. Web of Science Citations: 3.
ROMANELLI, JO AO PAULO; SILVA, LUIZ G. M.; GONCALVES, MARIA CAROLINA P.; NAVES, RAFAELA P.; DE ALMEIDA, DANILO ROBERTI ALVES; DE RESENDE, ANGELICA FARIA; RODRIGUES, RICARDO RIBEIRO. Repeatability of the searching process in reviews of restoration outcomes. RESTORATION ECOLOGY, v. 29, n. 8 AUG 2021. Web of Science Citations: 0.
GONCALVES, MARIA CAROLINA PEREIRA; AMARAL, JESSICA CRISTINA; FERNANDEZ-LAFUENTE, ROBERTO; DE SOUSA JUNIOR, RUY; TARDIOLI, PAULO WALDIR. Lipozyme 435-Mediated Synthesis of Xylose Oleate in Methyl Ethyl Ketone. Molecules, v. 26, n. 11 JUN 2021. Web of Science Citations: 0.

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