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Design of new biocatalizers by surface modifications of post-immobilization lipases for application in xylose oleate synthesis

Grant number: 19/23908-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2020
Effective date (End): February 28, 2023
Field of knowledge:Engineering - Chemical Engineering - Chemical Process Industries
Principal Investigator:Paulo Waldir Tardioli
Grantee:Maria Carolina Pereira Gonçalves
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:16/10636-8 - From the cell factory to the Biodiesel-Bioethanol integrated biorefinery: a systems approach applied to complex problems in micro and macroscales, AP.BIOEN.TEM


Under the concept of biorefinery, the biotechnology industry has been seeking the use of abundant renewable raw materials in order to convert them into high value-added products, in addition to meeting the principles of sustainability and green chemistry. In this context, sugar fatty esters, non-ionic surfactants, of low toxicity and biodegradable, appear like some of these products of economic value, are widely used in different industrial sectors. The synthesis of these compounds is usually performed by the chemical route, which requires a high energy demand and presents low selectivity, making the separation/purification steps of the products expensive. As an alternative to this method, it is proposed the use of an enzymatic route, with the possibility of obtaining a totally renewable product. In this project, it will be used lipases B from Candida antarctica (CALB) as biocatalysts, as well as xylose and oleic acid as substrates, aiming at the production of xylose fatty esters. The lipase will be immobilized on hydrophobic supports and treated with surface modifying agents in order to evaluate the effect of these modifications on the catalytic properties and stability of the new biocatalysts. (AU)