| Full text | |
| Author(s): Show less - |
Silva-Reis, Anamei
;
Rodrigues Brandao-Rangel, Maysa Alves
;
Moraes-Ferreira, Renilson
;
Gibson Goncalves-Alves, Thiago
;
Hugo Souza-Palmeira, Victor
;
Cristina Aquino-Santos, Helida
;
Lacerda Bachi, Andre Luis
;
Franco de Oliveira, Luis Vicente
;
Brandao Lopes-Martins, Rodrigo Alvaro
;
Oliveira-Silva, Iranse
;
Albertini, Regiane
;
Frison, Claudio Ricardo
;
Vieira, Rodolfo P.
Total Authors: 13
|
| Document type: | Journal article |
| Source: | FRONTIERS IN PHYSIOLOGY; v. 13, p. 14-pg., 2022-09-07. |
| Abstract | |
Background: Obesity impairs lung function and mechanics and leads to low-grade inflammation, but the effects of combined physical exercise (CPE) on that are unknown. Methods: We investigated the effects of 12 weeks of combined physical exercise (aerobic + resistance training), in non-obese (n = 12), overweight (n = 17), and obese grade I (n = 11) women. Lung function and lung mechanics were evaluated. The systemic immune response was evaluated by whole blood analysis and biomarker measurements, while pulmonary fibrotic biomarkers were evaluated in the breath condensate. Result: CPE improved forced vital capacity (FVC) % (p < 0.001) and peak expiratory flow (PEF) % (p < 0.0003) in the obese group; resistance of the respiratory system (R5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; resistance of proximal airways (R20Hz) in non-obese (p < 0.01), overweight (p < 0.0009), and obese (p < 0.0001) groups; resistance of distal airways (R5Hz-R20Hz) in non-obese (p < 0.01), overweight (p < 0.0012), and obese (p < 0.0001) groups; reactance of the respiratory system (X5Hz) in non-obese (p < 0.01), overweight (p < 0.0006), and obese (p < 0.0005) groups; impedance of the respiratory system (Z5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; central resistance (RCentral) in non-obese (p < 0.01), overweight (p < 0.001), and obese (p < 0.0003) groups; and the peripheral resistance (RPeripheral) in non-obese (p < 0.03), overweight (p < 0.001), and obese (p < 0.0002) groups. CPE reduced the pro-fibrotic IGF-1 levels in BC in overweight (p < 0.0094) and obese groups (p < 0.0001) and increased anti-fibrotic Klotho levels in BC in obese (p < 0.0001) groups, and reduced levels of exhaled nitric oxide in overweight (p < 0.03) and obese (p < 0.0001) groups. Conclusion: CPE improves lung function, mechanics, and pulmonary immune response in overweight and obese grade I women by increasing anti-fibrotic protein Klotho and reducing pro-fibrotic IGF-1. (AU) | |
| FAPESP's process: | 19/05739-0 - Role of kinins in the anti-inflammatory effects of aerobic training in experimental models of Asthma |
| Grantee: | Maysa Alves Rodrigues Brandão Rangel |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 20/03994-0 - Pro and anti-fibrotic proteins and asthma: is there a correlation betwween their levels with inflammation and airway resistance? |
| Grantee: | Victor Hugo Souza Palmeira |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 19/11244-4 - Effects of combined physical training on the pulmonary mechanics and function and on the pulmonary and systemic immune response of obese women |
| Grantee: | Anamei Silva Reis |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 19/11008-9 - The role of physical training in the pulmonary pro and anti-fibrotic responses of asthmatic individuals |
| Grantee: | Renilson Moraes Ferreira |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals |
| Grantee: | Rodolfo de Paula Vieira |
| Support Opportunities: | Research Grants - Young Investigators Grants |