Solid dispersions based on chitosan/hypromellose phthalate blends to modulate pharmaceutical properties of zidovudine

Author(s)

Pedreiro, Liliane Neves ; Boni, Fernanda Isadora ; Ferreira Cury, Beatriz Stringhetti ; Ferreira, Natalia Noronha ; Daflon Gremiao, Maria Palmira

• Document type: Journal article
• Source: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY; v. 27, n. 5, p. 10-pg., 2022-07-18.

Abstract

Zidovudine (AZT) has been widely used alone or in combination with other antiretroviral drugs for the treatment of human immunodeficiency virus. Its erratic oral bioavailability necessitates frequent administration of high doses, resulting in severe side effects. In this study, the design of mucoadhesive solid dispersions (SDs) based on chitosan (CS) and hypromellose phthalate (HP) was rationalized as a potential approach to modulate AZT physicochemical and pharmaceutical properties. SDs were prepared at different drug:polymer ratios, using an eco-friendly technique, which avoids the use of organic solvents. Particles with diameter from 56 to 73 mu m and negative zeta potentials (-27 to -32 mV) were successfully prepared, achieving high drug content. Infrared spectroscopy revealed interactions between polymers but no interactions between the polymers and AZT. Calorimetry and X-ray diffraction analyses showed that AZT was amorphized into the SDs. The mucoadhesive properties of SDs were evidenced, and the control of AZT release rates from the matrix was achieved, mainly in acid media. The simple, low-cost, and scalable technology proposed for production of SDs as a carrier platform for AZT is an innovative approach, and it proved to be a feasible strategy for modulation the physico-chemical, mucoadhesive, and release properties of the drug. (AU)

• FAPESP's process: 13/01670-0 - Development of mucoadhesives solid dispersion and polymeric nanoparticles of zidovudine and biological interaction evaluation with intestnal mucosa
• Grantee: Liliane Neves Pedreiro
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/25645-0 - BIOINSPIRED AND BIOMIMETIC NANOSTRUCTURED SYSTEMS FOR NOSE-TO-BRAIN ADMINISTRATION: A NOVEL PERSPECTIVE FOR GLIOBLASTOMA THERAPY
• Grantee: Natália Noronha Ferreira Naddeo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/26349-0 - Multifunctional polymeric systems based on microparticles containing nanocarriers for camptothecin colonic release
• Grantee: Fernanda Isadora Boni
• Support Opportunities: Scholarships in Brazil - Doctorate