Effect of the technique of photodynamic therapy against the main microorganisms responsible for periodontitis: A systematic review of in-vitro studies

Author(s)

Sales, Luciana Solera ; Miranda, Marina Lins ; de Oliveira, Analu Barros ; Ferrisse, Tulio Morandin ; Fontana, Carla Raquel ; Milward, Michael ; Brighenti, Fernanda Lourencao

• Document type: Journal article
• Source: ARCHIVES OF ORAL BIOLOGY; v. 138, p. 13-pg., 2022-03-28.

Abstract

Objective: The present study aimed to conduct a systematic review of the literature, to evaluate, in vitro, the effectiveness of the technique of photodynamic therapy against microorganisms associated with periodontal disease. Design: This systematic review was carried out in accordance with the items on the PRISMA checklist and Cochrane guidelines. Only in vitro studies that evaluated the effect of the technique of antimicrobial photodynamic therapy on periodontopathogenic microorganisms were included. Results: A total of 32 articles published between 2000 and 2021 were included for qualitative analysis. For microorganisms in suspension, 25 studies (78.12%) showed a reduction greater than or equal to 3 logs CFU/mL of species associated with periodontal disease. In biofilms, three studies (42.7%) showed a reduction greater than or equal to 3 logs CFU/mL. Conclusions: The results showed that the technique of photodynamic therapy may be a promising alternative to conventional antimicrobial approaches for reducing bacteria closely associated with periodontal disease. Some parameters (pre-irradiation time, type of photosensitizer, standardization of light parameters) need to be better established before conducting clinical studies. (AU)

• FAPESP's process: 19/26066-4 - Mucoadhesive multiparticulate system for controlled release of natural substances
• Grantee: Luciana Solera Sales
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 21/12931-5 - Anti-inflammatory, antioxidant and antimicrobial evaluation of mucoadhesive multiparticulate system containing botanical substance
• Grantee: Luciana Solera Sales
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 20/07110-0 - Potential of photodynamic therapy in modulating the inflammatory response and microbial virulence factors: evaluation in a model of three-dimensional co-cultures of gingival fibroblasts, Candida albicans and Staphylococcus aureus
• Grantee: Analú Barros de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/08375-0 - Maximization of the anti-caries and antibiofilm effect of conventional substances: evaluation in a polymicrobial biofilm model
• Grantee: Fernanda Lourenção Brighenti
• Support Opportunities: Regular Research Grants
• FAPESP's process: 21/01191-0 - Tolerance induction and Candida albicans's biofilm characterization after antimicrobial photodymamic therapy application
• Grantee: Túlio Morandin Ferrisse
• Support Opportunities: Scholarships in Brazil - Post-Doctoral