The adaptation of maternal energy metabolism to lactation and its underlying mechanisms

Author(s)

Anhe, Gabriel Forato ; Bordin, Silvana

• Document type: Journal article
• Source: Molecular and Cellular Endocrinology; v. 553, p. 22-pg., 2022-06-11.

Abstract

ABSTR A C T Maternal energy metabolism undergoes a singular adaptation during lactation that allows for the caloric enrichment of milk. Changes in the mammary gland, changes in the white adipose tissue, brown adipose tissue, liver, skeletal muscles and endocrine pancreas are pivotal for this adaptation. The present review details the landmark studies describing the enzymatic modulation and the endocrine signals behind these metabolic changes. We will also update this perspective with data from recent studies showing transcriptional and post-transcriptional mechanisms that mediate the adaptation of the maternal metabolism to lactation. The present text will also bring experimental and observational data that describe the long-term consequences that short periods of lactation impose to maternal metabolism. (AU)

• FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
• Grantee: Licio Augusto Velloso
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 20/13940-5 - Transitory history of obesity during different moments of life and its impact on allergy airway disease
• Grantee: Gabriel Forato Anhê
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/03196-0 - Molecular mechanisms involved in the metabolic inflexibility of rats submitted to metabolic programming induced by prenatal excess of glucocorticoids
• Grantee: Silvana Auxiliadora Bordin da Silva
• Support Opportunities: Regular Research Grants