Electrical/Spectroscopic Stability of Conducting and Biodegradable Graft-Copolymer

Author(s)

Da Silva, Arua Clayton ; Paschoal, Vitor Hugo ; Ribeiro, Mauro Carlos Costa ; de Torresi, Susana Ines Cordoba

• Document type: Journal article
• Source: MACROMOLECULAR CHEMISTRY AND PHYSICS; v. 223, n. 19, p. 12-pg., 2022-08-15.

Abstract

Development of conductive and biodegradable graft-copolymers is decisive for applied electrical biointerfaces. However, to make significant breakthrough in bioelectronics, addressing changing properties while degrading is essential. Herein, the conductive and biodegradable poly(3,4-ethylenedioxythiophene) and poly(D,L-lactic acid) copolymer (PEDOT-co-PDLLA) submitted to 35 days of degradation in either deionized water or phosphate-buffered saline (PBS) is reported. Cyclic voltammetry, electrochemical impedance spectroscopy, and Raman microspectroscopy are used to correlate the electrical stability with molecular/structural changes during the degradation process. Two different proportions 1:05 (higher PEDOT content) and 1:50 (lower PEDOT content) are evaluated. The PEDOT-co-PDLLA 1:05 presents stable charge storage capacitance (CSC) in PBS for 35 days. PEDOT-co-PDLLA 1:50 shows an enhanced CSC when freshly prepared. However, it promptly loses its capacitance. Raman spectroscopy demonstrates that 1:05 as-prepared shows mostly neutral state. Nonetheless, after 35 days of degradation, both graft-copolymers show similar spectra, with contributions of oxidized states. Although the increase in oxidized states moieties should improve the conductivity, its dependence on interconnectivity and its relevance to remaining electronically stable, intrinsically related to conductive/biodegradable proportions in as-prepared graft-copolymer are demonstrated. This work contributes to a better understanding of the electrical stability of graft-copolymers for designing smart devices in bioelectronics applications. (AU)

• FAPESP's process: 19/00207-0 - Density functional theory applyed to vibrational dynamics of crystals of ionic systems.
• Grantee: Vitor Hugo Paschoal
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/09353-6 - Biomaterials based on conducting biodegradable and biocompatible polymers
• Grantee: Aruã Clayton da Silva
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 17/00705-5 - Study of interaction between different proteins with a PEDOT-co-PLLA surface by EC-AFM
• Grantee: Aruã Clayton da Silva
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• FAPESP's process: 18/13492-2 - Synthetic and natural scaffolds applied to regenerative medicine
• Grantee: Luiz Henrique Catalani
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 16/21070-5 - Vibrational spectroscopy with spatial resolution
• Grantee: Mauro Carlos Costa Ribeiro
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/26308-7 - Optimization of the physicochemical properties of nano -structured materials for applications in molecular recognition, catalysis and energy conversion/storage
• Grantee: Roberto Manuel Torresi
• Support Opportunities: Research Projects - Thematic Grants