Pluronic (R) triblock copolymer-based nanoformulations for cancer therapy: A 10-year overview

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de Castro, Karine Cappuccio ; Coco, Julia Cedran ; dos Santos, Erica Mendes ; Ataide, Janaina Artem ; Martinez, Renata Miliani ; Monteiro do Nascimento, Monica Helena ; Prata, Joao ; Lopes da Fonte, Pedro Ricardo Martins ; Severino, Patricia ; Mazzola, Priscila Gava ; Baby, Andre Rolim ; Souto, Eliana Barbosa ; de Araujo, Daniele Ribeiro ; Lopes, Andre Moreni

• Document type: Journal article
• Source: JOURNAL OF CONTROLLED RELEASE; v. 353, p. 21-pg., 2022-12-17.

Abstract

This paper provides a review of the literature on the use of Pluronic (R) triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic (R) triblock copolymers as biological response modifiers and as pharmaceutical additives, adjuvants, and stabilizers, are also discussed. The advantages and limitations encountered in developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment are highlighted, in addition to inno-vative examples for improving tumor cytotoxicity while reducing side effects. (AU)

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• Support Opportunities: Scholarships in Brazil - Young Researchers
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• Support Opportunities: Regular Research Grants
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• Support Opportunities: Regular Research Grants
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• Support Opportunities: Research Grants - Young Investigators Grants
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• Grantee: Mayra Caroline Cunha Câmara
• Support Opportunities: Scholarships in Brazil - Scientific Initiation