Ex vivo and in vivo establishment of new chemopreventive properties of UV filters

• Grant number: 19/16169-0
• Support type: Regular Research Grants
• Duration: March 01, 2020 - February 28, 2022
• Field of knowledge: Health Sciences - Pharmacy
• Principal researcher: André Rolim Baby
• Grantee: André Rolim Baby
• Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Although there are standard methods for evaluating photoprotection (UVA and UVB), the damage chemoprevention mechanisms caused by ultraviolet radiation are not considered in these methods. Urocanic acid is a chromophore found in the skin and has been identified as an important immunosuppression mediator and carcinogenesis through its photoisomerization the trans form to the cis form induced by ultraviolet radiation. The development of a new method that explores the isomerization investigation it is necessary to elucidated possible mechanisms of protection. Although the sunscreens use is an important measure against sun damage, the elucidation of their effects in chemoprevention it is necessary. This project aims to develop and apply an ex vivo, non-invasive tape stripping methodology for the urocanic acid isomers' determination in the epidermis and to evaluate the penetration effect of these filters, as well as the protection against photoisomerization of urocanic acid after irradiation of UV light. In addition, the same procedure will be used to determine the antioxidant activity (antilipoperoxidative) of these sunscreens, and thus it is expected to map and elucidate the effects of photobiological protection of sunscreens of different absorption on the stratum corneum. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MUSSI, LILIAN; BABY, ANDRE ROLIM; CAMARGO JUNIOR, FLAVIO BUENO; PADOVANI, GIOVANA; SUFI, BIANCA DA SILVA; MAGALHAES, WAGNER VIDAL. Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays. Molecules, v. 26, n. 21 NOV 2021. Web of Science Citations: 0.

DE SOUZA GUEDES, LUCIANA; MARTINEZ, RENATA MILIANI; BOU-CHACRA, NADIA A.; VELASCO, MARIA VALERIA ROBLES; ROSADO, CATARINA; BABY, ANDRE ROLIM. An Overview on Topical Administration of Carotenoids and Coenzyme Q10 Loaded in Lipid Nanoparticles. ANTIOXIDANTS, v. 10, n. 7 JUL 2021. Web of Science Citations: 1.

FURUKAWA, JULIANA YUKA; MARTINEZ, RENATA MILIANI; MOROCHO-JACOME, ANA LUCIA; CASTILLO-GOMEZ, THALIA SELENE; PEREDA-CONTRERAS, VECXI JUDITH; ROSADO, CATARINA; VELASCO, MARIA VALERIA ROBLES; BABY, ANDRE ROLIM. Skin impacts from exposure to ultraviolet, visible, infrared, and artificial lights - a review. Journal of Cosmetic and Laser Therapy, v. 23, n. 1-2 JUL 2021. Web of Science Citations: 0.

SAUCE, RAFAEL; SALES DE OLIVEIRA PINTO, CLAUDINEIA APARECIDA; ROBLES VELASCO, MARIA VALERIA; ROSADO, CATARINA; BABY, ANDRE ROLIM. Ex vivo penetration analysis and anti-inflammatory efficacy of the association of ferulic acid and UV filters. European Journal of Pharmaceutical Sciences, v. 156, JAN 1 2021. Web of Science Citations: 0.

LIMA, FABIANA VIEIRA; AZEVEDO MARTINS, TERCIO ELYAN; MOROCHO-JACOME, ANA LUCIA; ALMEIDA, ISABEL FILIPA; ROSADO, CATARINA FIALHO; ROBLES VELASCO, MARIA VALERIA; BABY, ANDRE ROLIM. Analytical tools for urocanic acid determination in human samples: A review. JOURNAL OF SEPARATION SCIENCE, v. 44, n. 1, SI, p. 438-447, JAN 2021. Web of Science Citations: 0.

SAUCE, RAFAEL; SALES DE OLIVEIRA PINTO, CLAUDINEIA APARECIDA; AYALA-JARA, CARMEN; PRIETO, ZULITA ADRIANA; ROBLES VELASCO, MARIA VALERIA; BABY, ANDRE ROLIM. Preliminary Protocol Development of a HPLC-TBARS-EVSC (Ex Vivo Stratum Corneum) Assay for Skin Research: Application in a Sunscreen System. SCIENTIA PHARMACEUTICA, v. 89, n. 2 2021. Web of Science Citations: 0.

LIMA, FABIANA VIEIRA; MARTINS, TERCIO ELYAN AZEVEDO; MOROCHO-JACOME, ANA LUCIA; ALMEIDA, ISABEL FILIPA; ROSADO, CATARINA FIALHO; VELASCO, MARIA VALERIA ROBLES; BABY, ANDRE ROLIM. Analytical tools for urocanic acid determination in human samples: A review. JOURNAL OF SEPARATION SCIENCE, NOV 2020. Web of Science Citations: 0.

NERY, ERIKA MINUCI; MARTINEZ, RENATA MILIANI; VELASCO, MARIA VALERIA ROBLES; BABY, ANDRE ROLIM. A short review of alternative ingredients and technologies of inorganic UV filters. Journal of Cosmetic Dermatology, v. 20, n. 4 SEP 2020. Web of Science Citations: 0.

MOROCHO-JACOME, ANA LUCIA; FREIRE, THAMIRES BATELLO; DE OLIVEIRA, ANDRESSA COSTA; DE ALMEIDA, TANIA SANTOS; ROSADO, CATARINA; VELASCO, MARIA VALERIA ROBLES; BABY, ANDRE ROLIM. In vivo SPF from multifunctional sunscreen systems developed with natural compounds-A review. Journal of Cosmetic Dermatology, v. 20, n. 3 JUL 2020. Web of Science Citations: 1.