Muscle endoplasmic reticulum stress in exercise

Author(s)

Marafon, Bruno B. ; Pinto, Ana P. ; Ropelle, Eduardo R. ; de Moura, Leandro P. ; Cintra, Dennys E. ; Pauli, Jose R. ; da Silva, Adelino S. R.

• Document type: Journal article
• Source: ACTA PHYSIOLOGICA; v. 235, n. 1, p. 13-pg., 2022-02-21.

Abstract

The endoplasmic reticulum (ER) is an organelle responsible for the post-translational folding and modification of proteins. Under stress conditions, such as physical exercise, there is accumulation of misfolded proteins. The increased load of proteins in the ER results in ER stress, which activates the unfolded protein response (UPR). UPR is comprised of three parallel pathways, responsible for ensuring the quality of secreted proteins. Scientific studies show that resistance or endurance acute physical exercise can induce ER stress and activate the UPR pathways. On the other hand, regular moderate-intensity exercise can attenuate the responses of genes and proteins related to ER stress. However, these positive adaptations do not occur when exercise intensity and volume increase without adequate rest periods, which is observed in overtraining. The current review discusses the frontier-of-knowledge findings on the effects of different acute and chronic physical exercise protocols on skeletal muscle ER stress and its metabolic consequences. (AU)

• FAPESP's process: 21/08693-1 - Effect of global or conditional deletion (skeletal muscle) of the Nr1d1 gene on aging
• Grantee: Ana Paula Pinto
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 20/04269-8 - Role of TLR4 in endoplasmic reticulum stress induced by physical exercise in skeletal muscle
• Grantee: Bruno Brieda Marafon
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 19/11820-5 - Nr1d1 function on the aging-associated Sarcopenia
• Grantee: Adelino Sanchez Ramos da Silva
• Support Opportunities: Research Projects - Thematic Grants