The protective effect of the experimental TiF4 and chitosan toothpaste on erosive tooth wear in vitro

Author(s)

Francese, Monique Malta ; Bolzan Goncalves, Isabela Vieira ; Vertuan, Mariele ; de Souza, Beatriz Martines ; Magalhaes, Ana Carolina

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 12, n. 1, p. 7-pg., 2022-04-30.

Abstract

This study evaluated the protective effect of TiF4 and chitosan toothpaste on erosive tooth wear (ETW) in vitro. Enamel and dentin samples were randomly assigned to toothpastes (n = 12): (G1) TiF4 (1400 ppm F-), (G2) 0.5% chitosan (75% deacetylation, 500 mPas), (G3) TiF4 (1400 ppm F-) plus 0.5% chitosan (75% deacetylation, 500 mPas), (G4) Placebo, (G5) Erosion Protection (Elmex-GABA, 1400 ppm F-). Twelve samples were only eroded. All samples were submitted to erosive pH cycles and G1 to G5 to abrasive challenges using toothpastes' slurries plus 45 s of treatment, for 7 days. The final profile was overlaid to the baseline one for the ETW calculation (mu m). The data were subjected to Kruskal-Wallis/Dunn tests. TiF4 toothpastes, regardless of the presence of chitosan, were able to significantly reduce ETW compared to placebo, while chitosan alone was similar to placebo for both tissues. The toothpastes containing TiF4 were even superior to the commercial Elmex toothpaste on enamel, while they were similar on dentin; both were also significantly different from placebo for both tissues. TiF4 and Elmex toothpastes minimized the impact of brushing on eroded surface. In conclusion, TiF4 toothpastes, regardless the presence of chitosan, showed to be effective in minimizing ETW in vitro. (AU)

• FAPESP's process: 19/21797-0 - Effect of artificial saliva substitutes and fluoride application on the development of root caries under a microcosm biofilm model simulating patients subjected to head and neck radiation
• Grantee: Ana Carolina Magalhães
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/26369-4 - Effect of different citric candies on dental enamel wear in vitro
• Grantee: Isabela Vieira Bolzan Gonçalves
• Support Opportunities: Scholarships in Brazil - Scientific Initiation