| Full text | |
| Author(s): Show less - |
Zanella, Virgilio Gonzales
;
Wagner, Vivian Petersen
;
Schmidt, Many Rafaeli
;
Thieme, Stefanie
;
Correa, Cintia
;
Fonseca, Felipe Paiva
;
Rigon, Pettala
;
Barra, Marinez Bizarro
;
Kroef, Ricardo Gallicchio
;
Vargas, Pablo Agustin
;
Martins, Manoela Domingues
Total Authors: 11
|
| Document type: | Journal article |
| Source: | MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL; v. 26, n. 3, p. 11-pg., 2021-05-01. |
| Abstract | |
Background: Salivary gland cancers (SGC) represent an uncommon group of heterogeneous tumors. We performed a retrospective survey of SGC diagnosed in a reference center for treatment of malignant tumors from the south of Brazil aiming to determine the prognostic value of demographic, clinic and pathologic features. Material and Methods: Cases diagnosed as SGC between 2006 and 2016 were retrospectively collected. Medical records were examined to extract demographic, clinic, pathologic and follow-up information. Results: One-hundred and seven cases of SGC were identified. The most common SGC were mucoepidermoid carcinoma (MEC) (n = 39) followed by adenoid cystic carcinoma (AdCC) (n = 29). Among AdCCs, 55.2% of cases were classified as cribriform, 27.6% as tubular and 17.2% as solid. The tubular subtype had the highest percentage of cases with perineural invasion (p=0.01). Among MEC, 61.5% of cases were classified as low grade, 15.4% as intermediate grade and 19.9% as high grade. Low grade MEC had the lowest percentage of cases with perineural invasion (p=0.04). The 5-year survival for loco-regional control, disease-free survival (DFS) and disease-specific survival were 75%, 70% and 84%, respectively. The following features were associated with poor DFS: advancedage (p=0.03), rural residency (p=0.01), being a smoker or former smoker (p=0.01), pain (p=0.03), nodal metastasis (p<0.001), need for chemotherapy (p=0.02), neck dissection (p=0.04), perineural invasion (p=0.01), and being diagnosed with AdCC compared to MEC (p=0.02). Conclusions: The clinco-demographic and pathologic features identified as prognostic factors reveal the profile of patients at increased risk of recurrence and who would benefit from closer follow-up. (AU) | |
| FAPESP's process: | 16/21785-4 - Association of BDNF/TRKB signaling pathway with tumor agressiveness and cancer stem cell profile of malignant salivary gland tumors |
| Grantee: | Vivian Petersen Wagner |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |