Pedunculated, papillary giant cell fibroma in a pediatric patient: An immunohistochemical and in situ hybridization study

Author(s)

Silveira, Heitor Albergoni ; Silva-Sousa, Yara Teresinha Correa ; Reyes, Magdalena Raquel Torres ; Bernardini, Vanessa da Rocha ; Floriam, Luis Jose ; Leon, Jorge Esquiche

• Document type: Journal article
• Source: PEDIATRIC DENTAL JOURNAL; v. 33, n. 1, p. 6-pg., 2023-03-15.

Abstract

Giant cell fibroma (GCF), a benign fibrous proliferation, represents about 4.7% of all benign/ reactive fibrous growths in the oral cavity. GCF preferentially affects Caucasians, with a peak incidence in the third decade of life, and slight female predilection. Clinically, small gingival nodules (about 1.0 cm in diameter) are often observed. Herein, we report a 5-year-old girl who was referred for evaluation of a pedunculated nodule on the gingiva, resem-bling a human papillomavirus (HPV)-associated papillary lesion clinically and microscop-ically. HPV was not detected by immunohistochemical and in situ hybridization analysis in the excised surgical specimen. Thus, the lesion was diagnosed as GCF. Papillary surface projections are rarely described in GCF, but it should be included in its clinicopathological spectrum, especially in pediatric patients.(c) 2023 Japanese Society of Pediatric Dentistry. Published by Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region.
• Grantee: Jorge Esquiche León
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/12734-2 - Comparative immunohistochemical characterization of dendritic cell subgroups and viral oncogenesis in oral and oropharyngeal squamous cell carcinoma
• Grantee: Heitor Albergoni da Silveira
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 22/12760-9 - Clinicopathological correlation of the immune system, cell differentiation, angiogenesis, lipid metabolism and transcriptionally active HPV in a large series of head and neck squamous cell carcinomas
• Grantee: Jorge Esquiche León
• Support Opportunities: Regular Research Grants