Chemical composition and anti-proliferative activity of essential oils from some medicinal plants from Cachicadan, Region La Libertad, Peru

Author(s)

Meza, Eveleny Tirsa Vaca ; Vasquez-Kool, Jorge ; Sanchez, Noe Ildefonso Costilla ; Vieira, Amandio ; Rodrigues, Rodney Alexandre Ferreira ; Sartoratto, Adilson ; Granados, Angela del Pilar Flores ; Tello, Carmen Luisa Marin ; Ruiz, Ana Lucia Tasca Gois

• Document type: Journal article
• Source: NATURAL PRODUCT RESEARCH; v. N/A, p. 6-pg., 2023-07-15.

Abstract

This study evaluated the chemical composition and anti-proliferative activity of essential oils (EOs) obtained by hydrodistillation from seven medicinal plants from Cachicadan, La Libertad Region, Peru. Limonene (0.64 to 44.43%) and linalool (0.36 to 2.12%) were identified in all EOs by gas chromatography coupled to mass spectrometry analysis. The major components (relative intensity & GE; 10%) were cis-dihydro carvone, carvone, and cis-piperitone epoxide for Minthostachys mollis leaves; & beta;-pinene, limonene, and ledol for Lepechinia heteromorpha leaves; limonene, neral, and geranial for Aloysia citriodora, both leaves and flowers; & alpha;-pinene, and limonene for Myrcianthes myrsinoides leaves; and & alpha;-pinene, & beta;-myrcene, and (E)-& beta;-Ocimene for Dalea carthagenensis leaves. Constituted by (Z)-& beta;-ocimene, dihydrotagetone, (Z)-tagetone, and car-3-en-2-one, EO of Tagetes minuta leaves induced an irreversible cytostatic effect against MCF-7 human breast tumor cells. Further in vivo studies must be carried out to establish the safe and efficient dose of T. minuta EO as adjuvant treatment in oncological therapies. (AU)

• FAPESP's process: 14/23950-7 - In vitro evaluation of (anti)mutagenic activity of an aporphine alkaloid and its synthetic intermediates
• Grantee: Tamires Carolina Sedano
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 11/01114-4 - Antiproliferative and (anti)hormonal activities of extracts and fractions obtained from some Mentha species
• Grantee: Ana Lúcia Tasca Gois Ruiz
• Support Opportunities: Regular Research Grants