Two new naphthoquinone derivatives from Sinningia conspicua (Gesneriaceae)

Author(s)

Winiewski, Vanessa ; Verdan, Maria Helena ; Oliveira, Cristhian Santos ; Barreto Rodrigues, Tayna Eloyane ; Salvador, Marcos Jose ; Alves Stefanello, Maria Elida

• Document type: Journal article
• Source: NATURAL PRODUCT RESEARCH; v. N/A, p. 6-pg., 2023-08-29.

Abstract

Two new naphthoquinones, 7-hydroxy-2-O-methyldunniol (1) and 7-methoxy-2-O-methyldunniol (2) were isolated from the tubers of Sinningia conspicua (Seem.) G. Nicholson (Gesneriaceae). Nine known compounds were also obtained: 7-methoxydunniol (3), dunniol (4), 7-methoxy-alpha-dunnione (5), 7-hydroxydunnione (6), 2,4,4',6-tetramethoxychalcone (7), loureirin B (8), allo-calceolarioside A (9), beta-sitosterol (10) and stigmasterol (11). This is the first report of compounds 3 and 5 in Sinningia. n-Hexane, ethyl acetate and ethanol extracts, and compounds 1-5 were tested for cytotoxic activity against PC-3 (prostate) and SKMEL 103 (melanoma) human tumour cell lines and also against the 3T3 (fibroblast) non-cancer cell line. All samples were inactive. [GRAPHICS] . (AU)

• FAPESP's process: 12/09101-1 - Investigation of treatment with 24-epibrassinolide in plant development, profile of volatile constituents and biological activities of essential oils from Cymbopogon citratus, Cymbopogon flexuosus and Mentha pulegium
• Grantee: Marcos José Salvador
• Support Opportunities: Regular Research Grants
• FAPESP's process: 06/06079-4 - Search of antioxidants and antimicrobials in Gomphreneae tribe species
• Grantee: Marcos José Salvador
• Support Opportunities: Regular Research Grants
• FAPESP's process: 21/09693-5 - Use of microbiome technologies and bioassays for the search for new bioactive compounds in plants and symbionts: implications for metabolic responses, molecular diversity and bioactivity
• Grantee: Marcos José Salvador
• Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants
• FAPESP's process: 15/03726-8 - Integrated chemical and biological study in the search for bioactive substances in plants* and development of analytical procedures. *(Amaranthaceae, Gesneriaceae, Myrtaceae e Annonaceae)
• Grantee: Marcos José Salvador
• Support Opportunities: Regular Research Grants