| Full text | |
| Author(s): |
Feitor, Jessica F.
;
Brazaca, Lais C.
;
Lima, Amanda M.
;
Ferreira, Vinicius G.
;
Kassab, Giulia
;
Bagnato, Vanderlei S.
;
Carrilho, Emanuel
;
Cardoso, Daniel R.
Total Authors: 8
|
| Document type: | Journal article |
| Source: | ACS BIOMATERIALS SCIENCE & ENGINEERING; v. 9, n. 5, p. 15-pg., 2023-04-04. |
| Abstract | |
Globalization has raised concerns about spreading diseases and emphasized the need for quick and efficient methods for drug screening. Established drug efficacy and toxicity approaches have proven obsolete, with a high failure rate in clinical trials. Organ-on-a-chip has emerged as an essential alternative to outdated techniques, precisely simulating important characteristics of organs and predicting drug pharmacokinetics more ethically and efficiently. Although promising, most organ-ona-chip devices are still manufactured using principles and materials from the micromachining industry. The abusive use of plastic for traditional drug screening methods and device production should be considered when substituting technologies so that the compensation for the generation of plastic waste can be projected. This critical review outlines recent advances for organ-on-a-chip in the industry and estimates the possibility of scaling up its production. Moreover, it analyzes trends in organ-on-a-chip publications and provides suggestions for a more sustainable future for organ-on-a-chip research and production. (AU) | |
| FAPESP's process: | 17/01189-0 - Novel aging: technologies and solutions to manufacture novel dairy products for healthy aging |
| Grantee: | Daniel Rodrigues Cardoso |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/19750-3 - Exploring C4D detection for the development of innovative and low-cost microfluidic biosensors |
| Grantee: | Laís Canniatti Brazaca |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/18188-0 - Photodynamic inactivation of Bacterial Pneumonia with nebulization of the photosensitizer and extracorporeal illumination |
| Grantee: | Giulia Kassab |
| Support Opportunities: | Scholarships in Brazil - Doctorate |