Heterotypic communication as the promoter of phenotypic plasticity of cancer cells: The role of cancer secretomes

Author(s)

Zelanis, Andre ; Barcick, Uilla ; Racorti, Nathalia de Vasconcellos ; Salardani, Murilo

• Document type: Journal article
• Source: PROTEOMICS; v. N/A, p. 10-pg., 2023-07-20.

Abstract

Cellular communication relies on signaling circuits whose statuses are mainly modulated by soluble biomolecules such as carbohydrates, lipids, proteins, and metabolites as well as extracellular vesicles (EVs). Therefore, the active secretion of such biomolecules is critical for both cell homeostasis and proper pathophysiological responses in a timely fashion. In this context, proteins are among the main modulators of such biological responses. Hence, profiling cell line secretomes may be an opportunity for the identification of "signatures" of specific cell types (i.e., stromal or metastatic cells) with important prognostic/therapeutic value. This review will focus on the biological implications of cell secretomes in the context of cancer, as well as their functional roles in shaping the tumoral microenvironment (TME) and communication status of participating cells. (AU)

• FAPESP's process: 21/05087-3 - Evaluation of the effect of heterotypic signaling on tumor phenotype modulation in Melanoma
• Grantee: Uilla Barcick
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 19/07282-8 - Prospection of markers associated to proteolytic processing in plasma samples of patients with melanoma
• Grantee: André Zelanis Palitot Pereira
• Support Opportunities: Regular Research Grants