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Prospection of markers associated to proteolytic processing in plasma samples of patients with melanoma


Melanoma is an aggressive skin cancer and a lethal melanocytic neoplasm, with increasing annual number of cases (faster than any other solid tumor). Since the protein composition (proteome) of tumoral cells may be regarded as a description of cellular status, the evaluation of protein expression patterns in biopsy samples may lead to the discovery of cancer-related markers and new drug targets. In the context of tumoral development, proteolytic processing plays an important role, favoring the dispersion of tumor cells to distant sites (metastasis) as well as in mediating irreversible proteolytic signaling events. The main goal of this project is to probe the Biobank of the São Paulo of Cancer Institute (ICESP) aiming at validating prognostic markers that had already been identified in our previous research. Data obtained at this work will provide a systems-wide profile of proteolytic signaling in melanoma, with important translational potential, contributing to the understanding of the progression of melanoma. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SALARDANI, MURILO; BARCICK, UILLA; ZELANIS, ANDRE. Assessing proteolytic events in bioinformatic reanalysis of public secretome data from melanoma cell lines. BIOCHEMISTRY AND BIOPHYSICS REPORTS, v. 30, p. 4-pg., . (14/06579-3, 19/07282-8)
CAMACHO, MAURICIO FROTA; STUGINSKI, DANIEL R.; ANDRADE-SILVA, DEBORA; NISHIYAMA-JR, MILTON Y.; VALENTE, RICHARD H.; ZELANIS, ANDRE. A snapshot of Bothrops jararaca snake venom gland subcellular proteome. Biochimie, v. 214, p. 10-pg., . (14/06579-3, 19/07282-8)
PESSOTTI, DAYELLE S.; ANDRADE-SILVA, DEBORA; SERRANO, SOLANGE M. T.; ZELANIS, ANDRE. Heterotypic signaling between dermal fibroblasts and melanoma cells induces phenotypic plasticity and proteome rearrangement in malignant cells. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1868, n. 12, p. 9-pg., . (14/06579-3, 19/07282-8, 16/16935-7, 13/07467-1)
GALLO, GLORIA; BARCICK, UILLA; COELHO, CAMILA; SALARDANI, MURILO; CAMACHO, MAURICIO F.; CAJADO-CARVALHO, DANIELA; LOURES, FLAVIO V.; SERRANO, SOLANGE M. T.; HARDY, LEON; ZELANIS, ANDRE; et al. A proteomics-MM/PBSA dual approach for the analysis of SARS-CoV-2 main protease substrate peptide specificity. Peptides, v. 154, p. 8-pg., . (13/07467-1, 19/07282-8)
ZELANIS, ANDRE; BARCICK, UILLA; RACORTI, NATHALIA DE VASCONCELLOS; SALARDANI, MURILO. Heterotypic communication as the promoter of phenotypic plasticity of cancer cells: The role of cancer secretomes. PROTEOMICS, v. N/A, p. 10-pg., . (21/05087-3, 19/07282-8)

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