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Prospection of markers associated to proteolytic processing in plasma samples of patients with melanoma

Grant number: 19/07282-8
Support type:Regular Research Grants
Duration: March 01, 2020 - February 28, 2022
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:André Zelanis Palitot Pereira
Grantee:André Zelanis Palitot Pereira
Home Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
Assoc. researchers:Adriana Franco Paes Leme ; Miyuki Uno ; Roger Chammas

Abstract

Melanoma is an aggressive skin cancer and a lethal melanocytic neoplasm with increasing annual number of cases (faster than any other solid tumor). Since the protein composition (proteome) of tumoral cells may be regarded as a description of cellular status, the evaluation of protein expression patterns in biopsy samples may lead to the discovery of cancer-related markers and new drug targets. In the context of tumoral development, proteolytic processing plays an important role, favoring the dispersion of tumor cells to distant sites (metastasis) as well as in mediating irreversible proteolytic signaling events. The main goal of this project is to probe the Biobank of the São Paulo of Cancer Institute (ICESP) aiming at validating prognostic markers that had already been identified in our previous research. Data obtained at this work will provide a systems-wide profile of proteolytic signaling in melanoma, with important translational potential, contributing to the understanding of the progression of melanoma. (AU)