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Study of the glycoprotein composition in the surface of extracellular vesicles of plasma from patients with oral cancer and its correlation to prognosis

Grant number: 18/02180-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): May 01, 2018
Effective date (End): July 10, 2022
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Adriana Franco Paes Leme
Grantee:Carolina Moretto Carnielli
Host Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovações (Brasil). Campinas , SP, Brazil
Associated research grant:18/18496-6 - The role of alcohol treated-extracellular vesicles in oral cells transformation, AP.TEM
Associated scholarship(s):19/17840-8 - Ultra-deep glycome and glycoproteome profiling of oral cancer cells, tissues and extracellular vesicles to uncover new prognostic signatures, BE.EP.PD


Head and neck cancer corresponds to the sixth most frequent tumor malignancy worldwide. The majority of the cases is squamous cell carcinoma (OSCC), with a 5-year survival rate of 50%. The classification of the development stage of the disease is given by the TNM classification, also used for the determination of patient prognosis, in which the presence of lymph node metastasis is associated to the worst prognosis. The extracellular vesicles (EVs) are important mediators in the intercellular communication, playing an important role in the development of metastasis, as reported for some glycoprotein identified in EVs. Several glycoproteins from different types of tumors are used in the clinical practice for prognosis, monitoring, treatment response, among others. Thus, the main goal of this project is to search for potential prognostic markers such as glycoproteins of the surface of EVs from plasma of oral cancer patients, a source of liquid biopsy. In collaboration with ICESP (Cancer Institute of São Paulo), the plasma will be collected from oral cancer patients with clinical absence of lymph node metastasis (N0) and with T3 and T4, and from patients with lymph node metastasis (N+) and with T1 and T2. The EVs obtained from plasma of patients with or without lymph node metastasis will be analyzed by discovery based proteomics. The proteomic data will be correlated with clinicopathological features of the patients, with emphasis in metastasis. The selected glycoproteins will be verified in independent samples of a bigger cohort by targeted proteomics and then associated to clinical and pathological features of the patients. This project aims to indicate glycoproteins from the surface of extracellular vesicles that correlate with the presence of lymph node metastasis, and then, identify prognostic markers in patients with oral cancer (OSCC).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SA, JAMILE DE OLIVEIRA; TRINO, LUCIANA DANIELE; OLIVEIRA, ANA KARINA; BUSSO LOPES, ARIANE FIDELIS; GRANATO, DANIELA CAMPOS; COSTA NORMANDO, ANA GABRIELA; SANTOS, ERISON SANTANA; NEVES, LEANDRO XAVIER; CARNIELLI, CAROLINA MORETTO; PAES LEME, ADRIANA FRANCO. Proteomic approaches to assist in diagnosis and prognosis of oral cancer. EXPERT REVIEW OF PROTEOMICS, v. 18, n. 4, p. 261-284, . (18/11958-4, 19/21815-9, 18/18496-6, 18/12194-8, 19/18751-9, 19/09692-9, 18/02180-0, 18/15535-0, 18/15728-3, 16/19337-3)
PAULETTI, BIANCA A.; GRANATO, DANIELA C.; CARNIELLI, CAROLINA M.; CAMARA, GUILHERME A.; NORMANDO, ANA GABRIELA C.; TELLES, GUILHERME P.; LEME, ADRIANA F. PAES. Typic: A Practical and Robust Tool to Rank Proteotypic Peptides for Targeted Proteomics. JOURNAL OF PROTEOME RESEARCH, v. 22, n. 2, p. 7-pg., . (19/09692-9, 18/02180-0, 19/14828-7, 18/18496-6, 18/15535-0, 19/18751-9)
GRANATO, DANIELA C.; NEVES, LEANDRO X.; TRINO, LUCIANA D.; CARNIELLI, CAROLINA M.; LOPES, ARIANE F. B.; YOKOO, SAMI; PAULETTI, BIANCA A.; DOMINGUES, ROMENIA R.; SA, JAMILE O.; PERSINOTI, GABRIELLA; et al. Meta-omics analysis indicates the saliva microbiome and its proteins associated with the prognosis of oral cancer patients. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1869, n. 8, . (18/18496-6, 18/02180-0, 16/07846-0, 19/18751-9, 19/21815-9, 09/54067-3, 18/11958-4, 15/50590-4, 18/12194-8, 18/15728-3, 14/06485-9, 18/15535-0, 10/19278-0)

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