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Prospection of melanoma markers associated with protein N-terminal processing in human plasma samples

Grant number: 17/01374-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): April 01, 2017
Effective date (End): February 28, 2019
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal Investigator:André Zelanis Palitot Pereira
Grantee:Francine Fontes Ricco Simões
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
Associated research grant:14/06579-3 - System-wide analysis of N-terminal processing and protein diversity in the secretome of tumor cells, AP.JP


The search for biomarkers has been addressed by several investigators in the field of cancer biology, however, given the multitude of etiologic factors associated to oncogenesis, a number of challenges still need to be overcome. The imbalance of cellular homeostasis during oncogenesis has a marked effect on the repertoire of the proteins secreted by malignant cells (cellular secretome), as well as, upon the physiological processing events that occurs during or after protein synthesis. In this regard, the N-termini of eurakyotic proteins as well as the set of post translational modifications (PTMs) at the N-terminus or at the a-amino group has important implications on several ordinary biological processes, such as protein targeting, biological activity and protein turnover. Moreover, proteolytic processing is also responsible for the generation of new protein N-termini and comprises an essentially irreversible cell signaling process, affecting a number of biological pathways. During the last decade or so, investigators have started using high throughput methodologies (so-called 'omics') in order to understand the diversity of cellular secretomes as well as the complexity of PTMs in distinct biological scenarios. In this context, the main goal of this project is to perform a system-wide analysis of protein N-termini from plasma samples derived from patients with melanoma as well as to integrate these findings with relevant biological pathways that take place during oncogenesis. (AU)

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