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Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study

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Author(s):
Pessoa, Rodrigo ; de Souza, Daniela Raguer Valadao ; Nukui, Youko ; Pereira, Juliana ; Fernandes, Lorena Abreu ; Marcusso, Rosa Nascimento ; de Oliveira, Augusto Cesar Penalva ; Casseb, Jorge ; Duarte, Alberto Jose da Silva ; Sanabani, Sabri Saeed
Total Authors: 10
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 24, n. 13, p. 15-pg., 2023-07-01.
Abstract

Small RNAs (sRNAs) are epigenetic regulators of essential biological processes associated with the development and progression of leukemias, including adult T-cell leukemia/lymphoma (ATLL) caused by human T-cell lymphotropic virus type 1 (HTLV-1), an oncogenic human retrovirus originally discovered in a patient with adult T-cell leukemia/lymphoma. Here, we describe the sRNA profile of a 30-year-old woman with ATLL at the time of diagnosis and after maintenance therapy with the aim of correlating expression levels with response to therapy. (AU)

FAPESP's process: 22/09354-9 - Metabolomic and bacteriome profiling in HAM/TSP patients
Grantee:Sabri Saeed Mohammed Ahmed Al-Sanabani
Support Opportunities: Regular Research Grants