Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine

Author(s):Show less -

Ferreira, Filipe V. ; Souza, Alana G. ; Ajdary, Rubina ; de Souza, Lucas P. ; Lopes, Joao H. ; Correa, Daniel S. ; Siqueira, Gilberto ; Barud, Hernane S. ; Rosa, Derval dos S. ; Mattoso, Luiz H. C. ; Rojas, Orlando J.

• Document type: Journal article
• Source: BIOACTIVE MATERIALS; v. 29, p. 26-pg., 2023-11-01.

Abstract

We review the recent progress that have led to the development of porous materials based on cellulose nano structures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nano cellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure-property-function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed. (AU)

• FAPESP's process: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis
• Grantee: Osvaldo Novais de Oliveira Junior
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 20/07956-6 - Engineered biofabrication of biocellulose microcapsules containing arabinogalactan from biorefinery and cubosomes for colon-targeted delivery of drugs
• Grantee: Filipe Vargas Ferreira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/10636-8 - From the cell factory to the Biodiesel-Bioethanol integrated biorefinery: a systems approach applied to complex problems in micro and macroscales
• Grantee: Roberto de Campos Giordano
• Support Opportunities: Program for Research on Bioenergy (BIOEN) - Thematic Grants
• FAPESP's process: 22/03247-6 - Investigation of mesoporous nanoparticles from bioactive glasses containing niobium in bone tissue engineering
• Grantee: João Henrique Lopes
• Support Opportunities: Research Grants - Initial Project