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Engineered biofabrication of biocellulose microcapsules containing arabinogalactan from biorefinery and cubosomes for colon-targeted delivery of drugs

Grant number: 20/07956-6
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): June 01, 2021
Effective date (End): May 31, 2023
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal Investigator:Luiz Henrique Capparelli Mattoso
Grantee:Filipe Vargas Ferreira
Host Institution: Embrapa Instrumentação Agropecuária. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil
Associated research grant:16/10636-8 - From the cell factory to the Biodiesel-Bioethanol integrated biorefinery: a systems approach applied to complex problems in micro and macroscales, AP.BIOEN.TEM


Intestinal diseases are prevalent worldwide, and the development of sustainable multifunctional materials for controlled drug delivery directly to the colon has received much attention lately. A major challenge that still exists in the preparation of such materials is to achieve, simultaneously, drug protection during gastrointestinal transit, biocompatibility, good performance and simple, cheap and scalable manufacturing. In this context, engineered biofabrication using Bacterial Cellulose (BC) stands out because it allows the preparation of 3D capsules with the potential to controlled drug delivery. However, the use of such capsules is often limited to hydrophilic and large molecules due to the inherent hydrophilicity of BC and the mesh of its membranes. The addition of functional nanomaterials, such as cubosomes, is an alternative to overcome this limitation. This project aims to prepare and evaluate the in vitro performance of a new controlled-release system based on hybrid capsules BC/cubosomes with a pH-smart trigger mechanism for oral colon-targeted delivery of drugs. For this purpose, cubosomes carried with capecitabine - a drug for the Colon Cancer treatment - will be first prepared. Then, 3D capsules based on BC with a size of ~130 µm containing the cubosomes and arabinogalactan - polysaccharide from biorefinery with mucus-adhesive property - will be manufactured by microfluidics. Finally, the sodium alginate will be used in order to prepare pH-responsive capsules. The prepared materials will be comprehensively studied using advanced characterization techniques such as small-angle X-ray scattering (SAXS) and cryogenic Transmission Electron Microscopy (cryo-TEM). (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, FILIPE V.; SOUZA, ALANA G.; AJDARY, RUBINA; DE SOUZA, LUCAS P.; LOPES, JOAO H.; CORREA, DANIEL S.; SIQUEIRA, GILBERTO; BARUD, HERNANE S.; ROSA, DERVAL DOS S.; MATTOSO, LUIZ H. C.; et al. Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine. BIOACTIVE MATERIALS, v. 29, p. 26-pg., . (18/22214-6, 20/07956-6, 16/10636-8, 22/03247-6)
SANTOS, CAMILA C. O.; V. FERREIRA, FILIPE; PINHEIRO, IVANEI F.; LONA, LILIANE M. F.. Lignin valorization through polymer grafting by ring-opening polymerization and its application in health, packaging, and coating. JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, v. 11, n. 3, p. 20-pg., . (18/12831-8, 21/09341-1, 20/07956-6)
MEDEIROS, GUILHERME S.; OLIVEIRA, LUIS F. M.; FERREIRA, FILIPE, V; SOUZA, LUCAS P.; MARTIN, RICHARD A.; DE OLIVEIRA, IVONE R.; LOPES, JOAO H.. A perfect pair: Niobium- and gallium-doped ceramic biomaterial enabled by coupled synthesis method with potential application for bone regeneration and cancer-targeted therapy. Journal of Non-Crystalline Solids, v. 599, p. 11-pg., . (20/07956-6, 20/00598-7)
SOUZA, LUCAS; V. FERREIRA, FILIPE; LOPES, JOAO H.; CAMILLI, JOSE ANGELO; MARTIN, RICHARD A. .. Cancer Inhibition and In Vivo Osteointegration and Compatibility of Gallium-Doped Bioactive Glasses for Osteosarcoma Applications. ACS APPLIED MATERIALS & INTERFACES, v. N/A, p. 11-pg., . (20/07956-6)

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